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	Chemical constituents from the South China sea soft coral Sinularia humilis
	Li, Jie1,2; Huan, Xia-Juan1; Wu, Meng-Jun1; Chen, Zi-Hui1; Chen, Bao1; Miao, Ze-Hong1; Guo, Yue-Wei1; Li, Xu-Wen1
刊名	NATURAL PRODUCT RESEARCH
	2020-11-28
页码	7
关键词	Soft coral Sinularia humilis diterpenoids capnosane
ISSN号	1478-6419
DOI	10.1080/14786419.2020.1855645
通讯作者	Guo, Yue-Wei(ywguo@simm.ac.cn) ; Li, Xu-Wen(xwli@simm.ac.cn)
英文摘要	A new diterpenoid with an unusual capnosane skeleton, sinuhumilol A (1), alone with twelve known diverse compounds (2-13), were isolated from the South China Sea soft coral Sinularia humilis. Their structures and stereochemistry were elucidated by extensive spectroscopic analysis, quantum chemical calculations, and/or by the comparison of the spectroscopic data with those reported in the literature. In bioassay, compound 11 exhibited interesting specific cytotoxicity against the human colon adenocarcinoma cell line HT-29 with IC50 value of 12.5 mu M.
资助项目	National Natural Science Foundation of China[81991521] ; National Natural Science Foundation of China[21672230] ; National Key Research and Development Program of China[2018YFC0310903] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; Shanghai Rising-Star Program[20QA1411100] ; SA-SIBS Scholarship Program
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000601342400001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296319]
专题	中国科学院上海药物研究所
通讯作者	Guo, Yue-Wei; Li, Xu-Wen
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 2.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou, Peoples R China
推荐引用方式 GB/T 7714	Li, Jie,Huan, Xia-Juan,Wu, Meng-Jun,et al. Chemical constituents from the South China sea soft coral Sinularia humilis[J]. NATURAL PRODUCT RESEARCH,2020:7.
APA	Li, Jie.,Huan, Xia-Juan.,Wu, Meng-Jun.,Chen, Zi-Hui.,Chen, Bao.,...&Li, Xu-Wen.(2020).Chemical constituents from the South China sea soft coral Sinularia humilis.NATURAL PRODUCT RESEARCH,7.
MLA	Li, Jie,et al."Chemical constituents from the South China sea soft coral Sinularia humilis".NATURAL PRODUCT RESEARCH (2020):7.

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