Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects

doi:10.1002/cbdv.202000772

	Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects
	Yan, Huan 1,2; Li, Xiang 1,2,3; Ni, Wei 1,2; Zhao, Qing 3; Leng, Ying 4; Liu, Hai-Yang 1,2
刊名	CHEMISTRY & BIODIVERSITY
	2020-12-28
页码	7
关键词	Cyclocarya paliurus dammarane-type triterpenoid saponins 11β -HSD1 enzyme inhibitory activity
ISSN号	1612-1872
DOI	10.1002/cbdv.202000772
通讯作者	Liu, Hai-Yang(haiyangliu@mail.kib.ac.cn)
英文摘要	Two new dammarane-type triterpenoid saponins, 3 beta-(alpha-l-arabinopyranosyloxy)-24,25-dihydroxydammar-20-en-12 alpha-yl 6-deoxy-beta-d-glucopyranoside (1) and (24R)-3 beta-[(4-O-acetyl-alpha-l-arabinopyranosyl)oxy]-25-hydroxy-20,24-epoxydammaran-12 beta-yl 6-deoxy-beta-d-glucopyranoside (2), and fourteen known triterpenoids were isolated from the 70 % MeOH extract of the leaves of Cyclocarya paliurus. Their structures were established based on analyses of spectroscopic data. All compounds were tested for their inhibitory activities against the 11 beta-HSD1 enzyme. Hederagenin (13) exhibited moderate inhibitory effect for mouse 11 beta-HSD1 with an IC50 value of 0.16 +/- 0.04 mu M.
资助项目	National Natural Science Foundation of China[U1802287] ; National Natural Science Foundation of China[32000280] ; Ten Thousand Talents Plan of Yunnan Province for Industrial Technology Leading Talents ; Major Biomedical Project of Yunnan Province[2019ZF010] ; State Key Laboratory of Phytochemistry and Plant Resources in West China[P2019-ZZ02]
WOS关键词	ANTIOXIDANT ACTIVITIES ; CHEMICAL-CONSTITUENTS ; DEHYDROGENASE TYPE-1 ; TRITERPENOIDS ; POLYSACCHARIDE ; SAPONINS
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000602674800001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296305]
专题	中国科学院上海药物研究所
通讯作者	Liu, Hai-Yang
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Yunnan Univ Chinese Med, Kunming 650500, Yunnan, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Yan, Huan,Li, Xiang,Ni, Wei,et al. Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects[J]. CHEMISTRY & BIODIVERSITY,2020:7.
APA	Yan, Huan,Li, Xiang,Ni, Wei,Zhao, Qing,Leng, Ying,&Liu, Hai-Yang.(2020).Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects.CHEMISTRY & BIODIVERSITY,7.
MLA	Yan, Huan,et al."Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects".CHEMISTRY & BIODIVERSITY (2020):7.