Harnessing Genomic Stress for Antitumor Immunity

doi:10.1089/ars.2020.8221

	Harnessing Genomic Stress for Antitumor Immunity
	Pu, Congying 1,2; Tao, Siyao 1,2; Xu, Jun 1,2; Huang, Min 1,2
刊名	ANTIOXIDANTS & REDOX SIGNALING
	2020-12-04
页码	23
关键词	genomic stress cancer genomic instability antitumor immunity
ISSN号	1523-0864
DOI	10.1089/ars.2020.8221
通讯作者	Huang, Min(mhuang@simm.ac.cn)
英文摘要	Significance: Genomic instability, a hallmark of cancer, renders cancer cells susceptible to genomic stress from both endogenous and exogenous origins, resulting in the increased tendency to accrue DNA damage, chromosomal instability, or aberrant DNA localization. Apart from the cell autonomous tumor-promoting effects, genomic stress in cancer cells could have a profound impact on the tumor microenvironment. Recent Advances: Recently, it is increasingly appreciated that harnessing genomic stress could provide a promising strategy to revive antitumor immunity, and thereby offer new therapeutic opportunities in cancer treatment. Critical Issues: Genomic stress is closely intertwined with antitumor immunity via mechanisms involving the direct crosstalk with DNA damage response components, upregulation of immune-stimulatory/inhibitory ligands, release of damage-associated molecular patterns, increase of neoantigen repertoire, and activation of DNA sensing pathways. A better understanding of these mechanisms will provide molecular basis for exploiting the genomic stress to boost antitumor immunity. Future Directions: Future research should pay attention to the heterogeneity between individual cancers in the genomic instability and the associated immune response, and how to balance the toxicity and benefit by specifying the types, potency, and treatment sequence of genomic stress inducer in therapeutic practice.
资助项目	National Natural Science Foundation of China[81903640] ; National Natural Science Foundation of China[81821005] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020102]
WOS关键词	NF-KAPPA-B ; DNA-DAMAGE ; CHROMOSOMAL INSTABILITY ; COLORECTAL-CANCER ; TUMOR-CELLS ; CALRETICULIN EXPOSURE ; AIM2 INFLAMMASOME ; REPAIR DEFICIENCY ; CTLA-4 BLOCKADE ; DENDRITIC CELLS
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种	英语
出版者	MARY ANN LIEBERT, INC
WOS记录号	WOS:000595895400001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296214]
专题	中国科学院上海药物研究所
通讯作者	Huang, Min
作者单位	1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Pu, Congying,Tao, Siyao,Xu, Jun,et al. Harnessing Genomic Stress for Antitumor Immunity[J]. ANTIOXIDANTS & REDOX SIGNALING,2020:23.
APA	Pu, Congying,Tao, Siyao,Xu, Jun,&Huang, Min.(2020).Harnessing Genomic Stress for Antitumor Immunity.ANTIOXIDANTS & REDOX SIGNALING,23.
MLA	Pu, Congying,et al."Harnessing Genomic Stress for Antitumor Immunity".ANTIOXIDANTS & REDOX SIGNALING (2020):23.