Facile Synthesis and Size Control of 2D Cyclodextrin-Based Metal-Organic Frameworks Nanosheet for Topical Drug Delivery

doi:10.1002/ppsc.202000147

	Facile Synthesis and Size Control of 2D Cyclodextrin-Based Metal-Organic Frameworks Nanosheet for Topical Drug Delivery
	Bello, Mubarak G.2,3; Yang, Yingchao 2,3; Wang, Caifen 2; Wu, Li 2; Zhou, Panpan 2; Ding, Huanyu 2; Ge, Xiaofei 4; Guo, Tao 2; Wei, Lai 4; Zhang, Jiwen 1,2,3
刊名	PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
	2020-09-06
页码	13
关键词	gamma-cyclodextrin metal-organic frameworks cubes dexamethasone nanosheets ocular drug delivery
ISSN号	0934-0866
DOI	10.1002/ppsc.202000147
通讯作者	Wei, Lai(weil9@mail.sysu.edu.cn) ; Zhang, Jiwen(jwzhang@simm.ac.cn)
英文摘要	In this work, a 2D nanosheet (NS) of gamma-cyclodextrin (CD)-based metal-organic frameworks (MOFs) is synthesized through a facile green chemistry approach. NS-MOF carrier is constructed using a water system in a simple one-pot reaction involving CD and potassium carbonate. Particle size optimization is achieved by adjusting the reaction temperature and the introduction of crystal growth suppressor (appropriate proportion of acetone). The NS-MOF stability in aqueous medium is improved by polymerization reaction of crosslinked CD-MOF (CL-CD-MOF) without blocking its cavity for drug loading. The effects of particle geometry and size of nanoporous materials on their pharmacokinetics during drug delivery are compared between the sheet-like DXM@CL-NS-MOF and 3D-cubic-shaped DXM@CL-CD-MOF loaded with the same quantity of dexamethasone (DXM). The bioefficiency of these carriers in tear fluids and aqueous humors to deliver DXM is investigated in vivo. The results demonstrate that the 2D-nanosheet particles significantly improve precorneal residence time and intraocular bioavailability over the commercial Maxidex (0.1% dexamethasone) and its 3D-cubes counterpart of similar chemical composition. It suggests that the geometry of a carrier play a significant role in the biodistribution, and the carrier of CL-NS-MOF is a good candidate for ocular drug delivery.
资助项目	National Science and Technology Major Projects for the Major New Drugs Innovation and Development[2018ZX09721002-009] ; Research Foundation of the Shanghai Institute of Materia Medica[CASIMM0120182001] ; National Natural Science Foundation of China[81570828] ; Belt and Road Scholarship
WOS关键词	DEXAMETHASONE ; MICROEMULSIONS ; PHOSPHATE ; GEOMETRY
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000566321400001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/291610]
专题	中国科学院上海药物研究所
通讯作者	Wei, Lai; Zhang, Jiwen
作者单位	1.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, 2 Tiantan Xili, Beijing 100050, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 4.Sun Yat Sen Univ, State Key Lab Ophthalmol, Zhongshan Ophthalm Ctr, Guangzhou 510060, Peoples R China
推荐引用方式 GB/T 7714	Bello, Mubarak G.,Yang, Yingchao,Wang, Caifen,et al. Facile Synthesis and Size Control of 2D Cyclodextrin-Based Metal-Organic Frameworks Nanosheet for Topical Drug Delivery[J]. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,2020:13.
APA	Bello, Mubarak G..,Yang, Yingchao.,Wang, Caifen.,Wu, Li.,Zhou, Panpan.,...&Zhang, Jiwen.(2020).Facile Synthesis and Size Control of 2D Cyclodextrin-Based Metal-Organic Frameworks Nanosheet for Topical Drug Delivery.PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,13.
MLA	Bello, Mubarak G.,et al."Facile Synthesis and Size Control of 2D Cyclodextrin-Based Metal-Organic Frameworks Nanosheet for Topical Drug Delivery".PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION (2020):13.