Rare new bicyclic cembranoid ethers and a novel trihydroxy prenylated guaiane from the Xisha soft coral Lobophytum sp

doi:10.1016/j.bioorg.2020.104223

	Rare new bicyclic cembranoid ethers and a novel trihydroxy prenylated guaiane from the Xisha soft coral Lobophytum sp
	Li, Song-Wei 1,2; Cuadrado, Cristina 3; Huan, Xia-Juan 2; Yao, Li-Gong 2; Miao, Ze-Hong 2; Hernandez Daranas, Antonio 3; Guo, Yue-Wei 1,2
刊名	BIOORGANIC CHEMISTRY
	2020-10-01
卷号	103 页码:12
关键词	Soft coral Lobophytum Cembranoids Marine natural products Quantum mechanical calculations
ISSN号	0045-2068
DOI	10.1016/j.bioorg.2020.104223
通讯作者	Miao, Ze-Hong(zhmiao@simm.ac.cn) ; Hernandez Daranas, Antonio(adaranas@ipna.csic.es) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要	Seven new cembrane-type diterpenes, lobophytolins C-I (3-9), and one new prenylated-guiane-type diterpene, lobophytolin J (10), along with six known related ones (1, 2, 11-14), have been isolated from the soft coral Lobophytum sp. collected off the Xisha Island in the South China Sea. Their structures were elucidated by extensive spectroscopic analysis and quantum mechanical (QM)-NMR methods. The absolute configuration of lobophytolin H (8) was determined by the application of the modified Mosher's method and chemical transformation. Lobophytolin D (4) exhibited promising cytotoxicities in in vitro bioassays against HT-29, Capan-1, A549, and SNU-398 human cancer cell lines with IC50, values of 4.52, 6.62, 5.17, and 6.15 mu M, respectively.
资助项目	Natural Science Foundation of China[81991521] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[21672230] ; National Key Research and Development Program of China[2018YFC0310903] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; Spanish Ministry of Science and Innovation[PID2019-109476RB-C21] ; CSIC
WOS关键词	C-13 CHEMICAL-SHIFTS ; COMPUTATIONAL CHEMISTRY ; NMR-SPECTROSCOPY ; CONFIGURATION ; DITERPENOIDS ; PROTON ; DP4
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000575792900009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/291322]
专题	中国科学院上海药物研究所
通讯作者	Miao, Ze-Hong; Hernandez Daranas, Antonio; Guo, Yue-Wei
作者单位	1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xianlin Rd, Nanjing 210023, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 3.Consejo Super Invest Cient IPNA CSIC, Inst Prod Nat & Agrobiol, Tenerife 38206, Spain
推荐引用方式 GB/T 7714	Li, Song-Wei,Cuadrado, Cristina,Huan, Xia-Juan,et al. Rare new bicyclic cembranoid ethers and a novel trihydroxy prenylated guaiane from the Xisha soft coral Lobophytum sp[J]. BIOORGANIC CHEMISTRY,2020,103:12.
APA	Li, Song-Wei.,Cuadrado, Cristina.,Huan, Xia-Juan.,Yao, Li-Gong.,Miao, Ze-Hong.,...&Guo, Yue-Wei.(2020).Rare new bicyclic cembranoid ethers and a novel trihydroxy prenylated guaiane from the Xisha soft coral Lobophytum sp.BIOORGANIC CHEMISTRY,103,12.
MLA	Li, Song-Wei,et al."Rare new bicyclic cembranoid ethers and a novel trihydroxy prenylated guaiane from the Xisha soft coral Lobophytum sp".BIOORGANIC CHEMISTRY 103(2020):12.