Callistemonols A and B, Potent Antimicrobial Acylphloroglucinol Derivatives with Unusual Carbon Skeletons from Callistemon viminalis

doi:10.1021/acs.jnatprod.9b00064

	Callistemonols A and B, Potent Antimicrobial Acylphloroglucinol Derivatives with Unusual Carbon Skeletons from Callistemon viminalis
	Wu, Jie-Wei 1,2; Li, Bai-Lin 1; Tang, Chunping 2; Ke, Chang-Qang 2; Zhu, Nan-Lin 2; Qiu, Sheng-Xiang 3; Ye, Yang 2
刊名	JOURNAL OF NATURAL PRODUCTS
	2019-07-01
卷号	82 期号:7 页码:1917-1922
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.9b00064
通讯作者	Qiu, Sheng-Xiang(sxqiu@scbg.ac.cn) ; Ye, Yang(yye@mail.shcnc.ac.cn)
英文摘要	A phytochemical investigation on the leaves of Callistemon viminalis resulted in the isolation of two unusual compounds, callistemonols A (1) and B (2). Callistemonol A (1) possesses a novel skeleton of a furan ring fusing both an alpha,beta-triketone and a phloroglucinol unit, while callistemonol B (2) is an acylphloroglucinol derivative featuring two methyl substituents on a five-membered ring and an isovaleryl side chain. Their structures were fully characterized on the basis of extensive spectroscopic analysis, including 1D and 2D NMR parameters, as well as the IR and HRESIMS data. Callistemonol A (1) represents an example of a natural dibenzofuran with two phenyl moieties, and a plausible biogenetic pathway to generate this novel dibenzofuran through a C C bond-forming radical SAM enzyme is proposed. Moreover, antimicrobial assays, in conjunction with time-killing and biophysical studies, revealed that 1 and 2 exert potent bactericidal activities against a panel of methicillin-resistant pathogenic microbes.
资助项目	State Key Laboratory of Drug Research[SIMM1803KF-09] ; China Postdoctoral Science Foundation[2015M582436]
WOS关键词	PHLOROGLUCINOL DERIVATIVES ; ANTIBACTERIAL ACTIVITY ; LEAVES ; SPECTRUM ; ENZYMES ; OUTER
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000477917800021
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289117]
专题	中国科学院上海药物研究所
通讯作者	Qiu, Sheng-Xiang; Ye, Yang
作者单位	1.Guangzhou Univ Chinese Med, Math Engn Acad Chinese Med, Guangzhou 510006, Guangdong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res & Nat Prod, Chem Dept, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, South China Bot Garden, Guangdong Prov Key Lab Appl Bot, Program Nat Prod Chem Biol,Key Lab Plant Resource, Guangzhou 510650, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Wu, Jie-Wei,Li, Bai-Lin,Tang, Chunping,et al. Callistemonols A and B, Potent Antimicrobial Acylphloroglucinol Derivatives with Unusual Carbon Skeletons from Callistemon viminalis[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(7):1917-1922.
APA	Wu, Jie-Wei.,Li, Bai-Lin.,Tang, Chunping.,Ke, Chang-Qang.,Zhu, Nan-Lin.,...&Ye, Yang.(2019).Callistemonols A and B, Potent Antimicrobial Acylphloroglucinol Derivatives with Unusual Carbon Skeletons from Callistemon viminalis.JOURNAL OF NATURAL PRODUCTS,82(7),1917-1922.
MLA	Wu, Jie-Wei,et al."Callistemonols A and B, Potent Antimicrobial Acylphloroglucinol Derivatives with Unusual Carbon Skeletons from Callistemon viminalis".JOURNAL OF NATURAL PRODUCTS 82.7(2019):1917-1922.