Lignans from Isatis indigotica roots and their inhibitory effects on nitric oxide production

doi:10.1016/j.fitote.2019.104189

	Lignans from Isatis indigotica roots and their inhibitory effects on nitric oxide production
	Zhang, Dongdong 2; Li, Jingyi 2; Ruan, Deqing 2; Chen, Zhaoqiang 1; Zhu, Weiliang 1; Shi, Yanhong 3; Chen, Kaixian 1,2; Li, Yiming 2; Wang, Rui 2
刊名	FITOTERAPIA
	2019-09-01
卷号	137 页码:6
关键词	Isatis indigotica Lignans Structure determination Anti-inflammatory activity Nitric oxide production
ISSN号	0367-326X
DOI	10.1016/j.fitote.2019.104189
通讯作者	Li, Yiming(ymlius@163.com) ; Wang, Rui(wr@shutcm.edu.cn)
英文摘要	Seventeen lignans (1-17) were obtained from the roots of Isatis indigotica (I. indigotica). Among them, isatindigosesquilignans A-C (1-3) were deduced as three undescribed sesquilignans, which possess unusual carbon skeleton of aryltetralin unit connected with a C6-C3 moiety via a five-membered ring of C-3-C-8 ''-C-7 ''-O-C-4. Isatindigosesquilignans B and C were determined as the first examples of its glycosides from a natural source and a plausible biosynthetic pathway was proposed. Moreover, all of the isolated lignans were assayed regarding their inhibitory effects on nitric oxide (NO) production in RAW 264.7 cells and compounds 1, 2 and 7 showed inhibitory effects with IC50 values ranging from 19.46 mu M to 64.82 mu M.
资助项目	National Natural Science Foundation of China[81573571] ; National Natural Science Foundation of China[81673570] ; Excellent Academic Leaders Program of Shanghai[16XD1403500] ; Shanghai Scientific and Technological Innovation Program[18401931100] ; High level University Innovation Team ; Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine
WOS关键词	STEROIDAL GLYCOSIDES ; BIOACTIVE PHENOLICS ; ALKALOIDS ; CONSTITUENTS ; LEAVES ; FRUITS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000484878400005
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/288752]
专题	中国科学院上海药物研究所
通讯作者	Li, Yiming; Wang, Rui
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Inst TCM Int Standardizat, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Dongdong,Li, Jingyi,Ruan, Deqing,et al. Lignans from Isatis indigotica roots and their inhibitory effects on nitric oxide production[J]. FITOTERAPIA,2019,137:6.
APA	Zhang, Dongdong.,Li, Jingyi.,Ruan, Deqing.,Chen, Zhaoqiang.,Zhu, Weiliang.,...&Wang, Rui.(2019).Lignans from Isatis indigotica roots and their inhibitory effects on nitric oxide production.FITOTERAPIA,137,6.
MLA	Zhang, Dongdong,et al."Lignans from Isatis indigotica roots and their inhibitory effects on nitric oxide production".FITOTERAPIA 137(2019):6.