Cancer Cell Membrane-Camouflaged Nanorods with Endoplasmic Reticulum Targeting for Improved Antitumor Therapy

doi:10.1021/acsami.9b18388

	Cancer Cell Membrane-Camouflaged Nanorods with Endoplasmic Reticulum Targeting for Improved Antitumor Therapy
	Zhang, Wei 2; Yu, Miaorong 1,3; Xi, Ziyue 2; Nie, Di 1,3; Dai, Zhuo 3; Wang, Jie 2,3; Qian, Kun 1,3; Weng, Huixian 3; Gan, Yong 1,3; Xu, Lu 2
刊名	ACS APPLIED MATERIALS & INTERFACES
	2019-12-18
卷号	11 期号:50 页码:46614-46625
关键词	rod shape endoplasmic reticulum-tatgeted cancer cell membrane coating intracellular trafficking pancreatic tumor delivery
ISSN号	1944-8244
DOI	10.1021/acsami.9b18388
通讯作者	Xu, Lu(xulu@syphu.edu.cn)
英文摘要	Cell membrane-coated nanocarriers have been developed for drug delivery due to their enhanced blood circulation and tissue targeting capacities; however, previous works have generally focused on spherical nanoparticles and extracellular barriers. Many living organisms with different shapes, such as rod-shaped bacilli and rhabdovirus, display different functionalities regarding tissue penetration, cellular uptake, and intracellular distribution. Herein, we developed cancer cell membrane (CCM)-coated nanoparticles with spherical and rod shapes. CCM-coated nanorods (CRs) showed superior endocytosis efficiency compared with their spherical counterparts (CCM-coated nanospheres, CSs) due to the caveolin-mediated pathway. Moreover, CRs can effectively accumulate in the endoplasmic reticulum (ER) region and ship the loaded DOX to the nucleus at a considerable concentration, resulting in ER stress and subsequent apoptosis. After intravenous injection into human pancreatic adenocarcinoma cell (BxPC-3) and pancreatic stellate cell (HPSC) hybrid tumor-bearing nude mice, CRs exhibited improved immune escape ability, rapid extracellular matrix (ECM) penetration (8.2-fold higher than CSs), and enhanced tumor accumulation, further contributing to the enhanced antitumor efficacy. These findings may actually suggest the significance of shape design in improving current cell membrane-based drug delivery systems for effective subcellular targets and tumor therapy.
资助项目	National Natural Science Foundation of China[81803445] ; Liaoning Provincial Natural Science Foundation[2019-MS 302]
WOS关键词	MESOPOROUS SILICA NANOPARTICLES ; ER STRESS ; DRUG ; BIOCOMPATIBILITY ; DELIVERY ; SIZE ; TIME ; BIODISTRIBUTION ; PENETRATION ; ENDOCYTOSIS
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000503918300022
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/282213]
专题	中国科学院上海药物研究所
通讯作者	Xu, Lu
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Wei,Yu, Miaorong,Xi, Ziyue,et al. Cancer Cell Membrane-Camouflaged Nanorods with Endoplasmic Reticulum Targeting for Improved Antitumor Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(50):46614-46625.
APA	Zhang, Wei.,Yu, Miaorong.,Xi, Ziyue.,Nie, Di.,Dai, Zhuo.,...&Xu, Lu.(2019).Cancer Cell Membrane-Camouflaged Nanorods with Endoplasmic Reticulum Targeting for Improved Antitumor Therapy.ACS APPLIED MATERIALS & INTERFACES,11(50),46614-46625.
MLA	Zhang, Wei,et al."Cancer Cell Membrane-Camouflaged Nanorods with Endoplasmic Reticulum Targeting for Improved Antitumor Therapy".ACS APPLIED MATERIALS & INTERFACES 11.50(2019):46614-46625.