Amphiphilic drug-drug conjugate for cancer therapy with combination of chemotherapeutic and antiangiogenesis drugs

doi:10.1007/s11426-019-9602-4

	Amphiphilic drug-drug conjugate for cancer therapy with combination of chemotherapeutic and antiangiogenesis drugs
	Sun, Mo 2; Qian, Qiuhui 2; Shi, Leilei 2; Xu, Li 2; Liu, Qunfang 1; Zhou, Linzhu 2; Zhu, Xinyuan 2; Yue, Jian-Min 1; Yan, Deyue 2
刊名	SCIENCE CHINA-CHEMISTRY
	2019-10-21
页码	7
关键词	nanoparticle combination therapy cancer treatment supramolecular chemistry
ISSN号	1674-7291
DOI	10.1007/s11426-019-9602-4
通讯作者	Zhu, Xinyuan(xyzhu@sjtu.edu.cn) ; Yue, Jian-Min(jmyue@mail.shcnc.ac.cn) ; Yan, Deyue(dyyan@sjtu.edu.cn)
英文摘要	The progression and metastasis of solid tumors strongly rely on the process of forming nascent blood vessels. However, using angiogenesis inhibitors alone does not meet the cancer treatment needs. Herein, we used the amphiphilic drug-drug conjugate (ADDC) strategy to fabricate a new drug conjugate with the combination of chemotherapeutic drug and antiangiogenesis drug together. With one-step esterification of hydrophilic floxuridine (FUDR) and hydrophobic pseudolaric acid B (PAB), the conjugate was synthesized. The amphiphilic property of FUDR-PAB conjugate induced the self-assembly to form nanoparticles in water. From further in vitro and in vivo experiments, this FUDR-PAB conjugate does not only have a high antitumor effect, but also shows efficient antianiogenesis property. These results offer a promising ADDC strategy for designing drugs with combination of chemotherapeutic drug and antiangiogenesis drug together.
资助项目	National Basic Research Program[2015CB931801] ; National Natural Science Foundation of China[51690151] ; National Natural Science Foundation of China[21504055]
WOS关键词	TARGETED DELIVERY ; NANOPARTICLES ; FLOXURIDINE ; NANODRUG ; NANOMEDICINE ; DOXORUBICIN ; RESISTANCE ; PRODRUG ; TUMORS
WOS研究方向	Chemistry
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000492171000003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281777]
专题	中国科学院上海药物研究所
通讯作者	Zhu, Xinyuan; Yue, Jian-Min; Yan, Deyue
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, State Key Lab Met Matrix Composites, Shanghai 200240, Peoples R China
推荐引用方式 GB/T 7714	Sun, Mo,Qian, Qiuhui,Shi, Leilei,et al. Amphiphilic drug-drug conjugate for cancer therapy with combination of chemotherapeutic and antiangiogenesis drugs[J]. SCIENCE CHINA-CHEMISTRY,2019:7.
APA	Sun, Mo.,Qian, Qiuhui.,Shi, Leilei.,Xu, Li.,Liu, Qunfang.,...&Yan, Deyue.(2019).Amphiphilic drug-drug conjugate for cancer therapy with combination of chemotherapeutic and antiangiogenesis drugs.SCIENCE CHINA-CHEMISTRY,7.
MLA	Sun, Mo,et al."Amphiphilic drug-drug conjugate for cancer therapy with combination of chemotherapeutic and antiangiogenesis drugs".SCIENCE CHINA-CHEMISTRY (2019):7.