A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer

doi:10.1002/jbio.201960152

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer
	Zhang, Zeyu 5,6; Qu, Yawei 7,8; Cao, Yu 3; Shi, Xiaojing 4,6; Guo, Hongbo 2; Zhang, Xiaojun 9; Zheng, Sheng 7; Liu, Haifeng 7; Hu, Zhenhua 4,6; Tian, Jie 1,4,5,6
刊名	JOURNAL OF BIOPHOTONICS
	2019-12-16
页码	11
关键词	Cerenkov luminescence imaging colorectal cancer image-guided surgery in vivo
ISSN号	1864-063X
DOI	10.1002/jbio.201960152
通讯作者	Liu, Haifeng(haifengliu333@163.com) ; Hu, Zhenhua() ; Tian, Jie(tian@ieee.org)
英文摘要	Intraoperative Cerenkov luminescence imaging (CLI) can effectively improve the performance of tumor surgery. Nevertheless, the existing approaches are still unsatisfying to the clinical demands of open surgery. This study develops a novel intraoperative in vivo CLI approach to investigate the potential and value of Cerenkov luminescence (CL) image-guided surgery. A system characterized with high sensitivity (19.61 kBq mL(-1 18)F-FDG) and desirable spatial resolution (88.34 mu m) is developed. CL image-guided surgery is performed on colorectal cancer (CRC) models of mice and swine. Tumor surgery is guided by the static CL images, and the resection quality is evaluated quantitatively and contrasted with other imaging modalities exemplified by bioluminescence imaging (BLI). The in vivo results demonstrated the effectiveness of the proposed intraoperative CLI approach for removing primary and metastatic CRC. Safety of performing in vivo CL image-guided surgery is verified as well through radiation measurements of related staffs. Overall, the developed intraoperative in vivo CLI approach can efficiently improve the cancer treatment.
资助项目	Beijing Nova Program[Z181100006218046] ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[YZ201672] ; National Key Research and Development Program of China[2016YFC0102600] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China[61622117] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81671759] ; National Natural Science Foundation of China[81930053] ; Institute of Automation, Chinese Academy of Sciences
WOS关键词	SYSTEM ; FEASIBILITY ; SENSITIVITY ; RESOLUTION ; ENDOSCOPY ; RADIATION ; POWER
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics ; Optics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000502795400001
资助机构	Beijing Nova Program ; Chinese Academy of Sciences ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; Institute of Automation, Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/29421]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Liu, Haifeng; Hu, Zhenhua; Tian, Jie
作者单位	1.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing, Peoples R China 2.Northwest Univ, Sch Informat Sci & Technol, Xian, Shaanxi, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 3, Dept Anorectal, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Sch Life Sci & Technol, Minist Educ, Xian, Shaanxi, Peoples R China 6.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing Key Lab Mol Imaging,CAS Key Lab Mol Imagi, Beijing, Peoples R China 7.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 3, Dept Gastroenterol, 69 Yongding Rd, Beijing, Peoples R China 8.Harbin Inst Technol, Dept Control Sci & Engn, Harbin, Heilongjiang, Peoples R China 9.Chinese Peoples Liberat Army Gen Hosp, Dept Nucl Med, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Zeyu,Qu, Yawei,Cao, Yu,et al. A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer[J]. JOURNAL OF BIOPHOTONICS,2019:11.
APA	Zhang, Zeyu.,Qu, Yawei.,Cao, Yu.,Shi, Xiaojing.,Guo, Hongbo.,...&Tian, Jie.(2019).A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer.JOURNAL OF BIOPHOTONICS,11.
MLA	Zhang, Zeyu,et al."A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer".JOURNAL OF BIOPHOTONICS (2019):11.