Degradable magnetic-response photoacoustic/up-conversion luminescence imaging-guided photodynamic/photothermal antitumor therapy

doi:10.1039/c9bm00853e

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Degradable magnetic-response photoacoustic/up-conversion luminescence imaging-guided photodynamic/photothermal antitumor therapy
	Lv, Ruichan 1; Jiang, Xue 1; Yang, Fan 1; Wang, Yanxing 1; Feng, Miao 1; Liu, Jun 1; Tian, Jie 1,2
刊名	BIOMATERIALS SCIENCE
	2019-11-01
卷号	7 期号:11 页码:4558-4567
ISSN号	2047-4830
DOI	10.1039/c9bm00853e
通讯作者	Lv, Ruichan(rclv@xidian.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要	In this research, a degradable uniform mesoporous platform was designed as an imaging-guided photothermal therapy (PTT)/photodynamic therapy (PDT) agent. Fe3O4 nanoparticles were prepared using the solvothermal method, and a layer of mesoporous SiO2 was coated onto them using sol-gel and etching processes, then these ultra-small up-conversion nanoparticles (UCNPs) were loaded into the porous structure through electrostatic conjunction and physical absorption. By adjusting the etching processes, Fe3O4@mSiO(2) and mSiO(2) with a high surface area as a carrier host could be obtained separately. Importantly, the platform could recognize the tumor cells with a magnetic-response and then present strong photoacoustic (PA) and up-conversion luminescence (UCL) signals, and Fe3O4@mSiO(2) as drug carriers could be degraded by hydrolysis. Furthermore, under a single 808 nm laser, the temperature of Fe3O4@mSiO(2)@UCNPs rises much higher than that of the surrounding tissues, and produces a large amount of singlet oxygen because a strong crossover occurs between the emitted blue emission of the UCNPs and the absorbance region of Fe3O4. Therefore, the Fe3O4@mSiO(2)@UCNPs can be used as a magnetic-targeted dual-modal imaging guided PTT/PDT theranostic probe.
资助项目	Natural Science Foundation of China[NSFC 81801744] ; Natural Science Foundation of China[81227901] ; National Key R&D Program of China[2017YFA0205202] ; Fundamental Research Funds for the Central Universities[XJS17011] ; Fundamental Research Funds for the Central Universities[JBX181202]
WOS关键词	PHOTODYNAMIC THERAPY ; INORGANIC NANOPARTICLES ; CANCER ; NANOCOMPOSITES ; NANOPLATFORM ; DESIGN ; LIGHT
WOS研究方向	Materials Science
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000498818900035
资助机构	Natural Science Foundation of China ; National Key R&D Program of China ; Fundamental Research Funds for the Central Universities
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/29353]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Lv, Ruichan; Tian, Jie
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Lv, Ruichan,Jiang, Xue,Yang, Fan,et al. Degradable magnetic-response photoacoustic/up-conversion luminescence imaging-guided photodynamic/photothermal antitumor therapy[J]. BIOMATERIALS SCIENCE,2019,7(11):4558-4567.
APA	Lv, Ruichan.,Jiang, Xue.,Yang, Fan.,Wang, Yanxing.,Feng, Miao.,...&Tian, Jie.(2019).Degradable magnetic-response photoacoustic/up-conversion luminescence imaging-guided photodynamic/photothermal antitumor therapy.BIOMATERIALS SCIENCE,7(11),4558-4567.
MLA	Lv, Ruichan,et al."Degradable magnetic-response photoacoustic/up-conversion luminescence imaging-guided photodynamic/photothermal antitumor therapy".BIOMATERIALS SCIENCE 7.11(2019):4558-4567.