Quantitative microbiome profiling links microbial community variation to the intestine regeneration rate of the sea cucumber Apostichopus japonicus

doi:10.1016/j.ygeno.2020.09.017

CORC > 海洋研究所 > 中国科学院海洋研究所 > 海洋生态与环境科学重点实验室

	Quantitative microbiome profiling links microbial community variation to the intestine regeneration rate of the sea cucumber Apostichopus japonicus
	Zhang, Hongxia 2,3,4,5; Wang, Qing 1,3; Zhao, Jianmin 1,3; Liu, Shilin 2,3,4,5; Zhang, Libin 2,3,4,5,7; Zhao, Ye 8; Yang, Hongsheng 2,3,4,5,6; Sun, Lina 2,3,4,5
刊名	GENOMICS
	2020-11-01
卷号	112 期号:6 页码:5012-5020
关键词	Apostichopus japonicus Intestine regeneration Intestinal microbiota Quantitative microbiome Regeneration rate
ISSN号	0888-7543
DOI	10.1016/j.ygeno.2020.09.017
通讯作者	Sun, Lina(sunlina@qdio.ac.cn)
英文摘要	The intestinal microbiota may play important roles in regenerating intestine of the sea cucumber Apostichopus japonicus, the underlying mechanism remains unclear. In the present study, a germ-free sea cucumber model was developed, and the intestinal microbial differentiation of faster and slower regenerating A. japonicus individuals during intestine regeneration was analyzed. The results revealed that depletion of the intestinal microbiota resulted in elevated abundance of the potential key players Flavobacteriaceae and Rhodobacteraceae during intestine regeneration and thus promoted the intestine regeneration rate of A. japonicus. Metagenomic analysis revealed that the increased abundance of Flavobacteriaceae elevated the enrichment of genes associated with carbohydrate utilization, whereas the abundant Rhodobacteraceae-enriched genes were associated with polyhydroxybutyrate production. We identified microbiota abundance as a key driver of microbial community alterations, especially beneficial microbiota members, in the developing intestine of A. japonicus. This study provides new insights into the mechanism of host-microbiota interactions related to organ regeneration.
资助项目	National Natural Science Foundation of China[41776162] ; China Postdoctoral Science Foundation[2018M642712] ; Youth Talent Support Program of the Laboratory for Marine Ecology and Environmental Science ; Pilot National Laboratory for Marine Science and Technology (Qingdao)[LMEES-YTSP-2018-01-09] ; Taishan Scholars Program (Distinguished Taishan Scholars), TwoHundred Talents Plan of Yantai[Y839081021] ; Youth Innovation Promotion Association CAS[2016196] ; Youth Innovation Promotion Association CAS[2019209] ; Chinese Academy of Sciences[KFJ-STS-ZDTP-023] ; Chinese Academy of Sciences[133137KYSB20180069]
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000600731500010
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/169438]
专题	海洋研究所_海洋生态与环境科学重点实验室
通讯作者	Sun, Lina
作者单位	1.Chinese Acad Sci, CAS Res & Dev Ctr Efficient Utilizat Coastal Bior, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 6.Chinese Acad Sci, Innovat Seed Design, Wuhan, Peoples R China 7.Minist Nat Resources, Inst Oceanog 2, State Key Lab Satellite Ocean Environm Dynam, Hangzhou 310012, Peoples R China 8.Yantai Univ, Ocean Sch, Yantai 264005, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Hongxia,Wang, Qing,Zhao, Jianmin,et al. Quantitative microbiome profiling links microbial community variation to the intestine regeneration rate of the sea cucumber Apostichopus japonicus[J]. GENOMICS,2020,112(6):5012-5020.
APA	Zhang, Hongxia.,Wang, Qing.,Zhao, Jianmin.,Liu, Shilin.,Zhang, Libin.,...&Sun, Lina.(2020).Quantitative microbiome profiling links microbial community variation to the intestine regeneration rate of the sea cucumber Apostichopus japonicus.GENOMICS,112(6),5012-5020.
MLA	Zhang, Hongxia,et al."Quantitative microbiome profiling links microbial community variation to the intestine regeneration rate of the sea cucumber Apostichopus japonicus".GENOMICS 112.6(2020):5012-5020.