Association between TNF-alpha polymorphism and the age of first suicide attempt in chronic patients with schizophrenia | |
Lang, Xiaoe1; Trihn, Tammy H.2; Wu, Hanjing Emily2; Tong, Yongsheng3; Xiu, Meihong3; Zhang, Xiang Yang4,5 | |
刊名 | AGING-US |
2020-01-31 | |
卷号 | 12期号:2页码:1433-1445 |
关键词 | schizophrenia genotype suicide TNF-alpha association |
ISSN号 | 1945-4589 |
DOI | 10.18632/aging.102692 |
产权排序 | 4 |
文献子类 | article |
英文摘要 | Patients with schizophrenia (SCZ) exhibit higher suicide rates than the general population. However, the molecular mechanism remains poorly understood. Tumor necrosis factor (TNF)-alpha polymorphisms have been repeatedly indicated to play a pathogenetic role in various mental disorders, but none of these studies focused on the susceptibility to suicidal behavior in SCZ. We recruited 1087 chronic inpatients with SCZ and 576 controls to assess the psychopathological symptoms of SCZ using the Positive and Negative Syndrome Scale scales. We selected 2 polymorphisms (-308G>A and -1031C>T) in the TNF-alpha gene and analyzed their associations with SCZ and suicide. Our results showed that TNF-alpha -308G>A and -1031C>T were not related to SCZ and suicide. However, we found that suicide attempters with the C allele carriers exhibited suicidal behaviors significantly later than those with TT genotype in the SCZ patients. The haplotype containing the T allele of the -1031 was significantly associated with the age of suicide initiation. Further logistic regression analysis showed that -1031C>T interacted with psychopathological symptoms and drinking, age of smoking, and related to the initiation age of suicide attempts. Our study demonstrated that the TNF-alpha variants may affect the age at which suicide attempts started among SCZ suicide attempters. |
资助项目 | Key Research Project in Shanxi Province[201803D31098] ; Wu Jieping Medical Foundation[320.6750.18336] ; National Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81000509] |
WOS关键词 | NECROSIS-FACTOR-ALPHA ; ADMIXTURE ANALYSIS ; GENE POLYMORPHISM ; PREFRONTAL CORTEX ; BIPOLAR DISORDER ; CYTOKINE LEVELS ; NO ASSOCIATION ; METAANALYSIS ; PROMOTER ; MARKERS |
WOS研究方向 | Cell Biology ; Geriatrics & Gerontology |
语种 | 英语 |
出版者 | IMPACT JOURNALS LLC |
WOS记录号 | WOS:000511120700027 |
资助机构 | Key Research Project in Shanxi Province ; Wu Jieping Medical Foundation ; National Natural Science Foundation of China |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/30833] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Lang, Xiaoe; Xiu, Meihong; Zhang, Xiang Yang |
作者单位 | 1.Shanxi Med Univ, Clin Med Coll 1, Dept Psychiat, Taiyuan, Shanxi, Peoples R China 2.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 3.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Lang, Xiaoe,Trihn, Tammy H.,Wu, Hanjing Emily,et al. Association between TNF-alpha polymorphism and the age of first suicide attempt in chronic patients with schizophrenia[J]. AGING-US,2020,12(2):1433-1445. |
APA | Lang, Xiaoe,Trihn, Tammy H.,Wu, Hanjing Emily,Tong, Yongsheng,Xiu, Meihong,&Zhang, Xiang Yang.(2020).Association between TNF-alpha polymorphism and the age of first suicide attempt in chronic patients with schizophrenia.AGING-US,12(2),1433-1445. |
MLA | Lang, Xiaoe,et al."Association between TNF-alpha polymorphism and the age of first suicide attempt in chronic patients with schizophrenia".AGING-US 12.2(2020):1433-1445. |
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