Crystal-Amorphous Core-Shell Structure Synergistically Enabling TiO2 Nanoparticles' Remarkable SERS Sensitivity for Cancer Cell Imaging

doi:10.1021/acsami.9b17150

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	Crystal-Amorphous Core-Shell Structure Synergistically Enabling TiO2 Nanoparticles' Remarkable SERS Sensitivity for Cancer Cell Imaging
	Lin, Jie ; Ren, Wenzhi ; Li, Anran ; Yao, Chenyang ; Chen, Tianxiang ; Ma, Xuehua ; Wang, Xiaotian ; Wu, Aiguo
刊名	ACS APPLIED MATERIALS & INTERFACES
	2020
卷号	12 期号:4 页码:4204-4211
关键词	ENHANCED RAMAN-SCATTERING TUMOR-CELLS MOLECULES GRAPHENE SPECTROSCOPY
DOI	10.1021/acsami.9b17150
英文摘要	Exploring novel surface-enhanced Raman scattering (SERS) active materials with high detection sensitivity, excellent biocompatibility, low biotoxicity, and good spectral stability is urgently required for efficacious cancer cell diagnosis. Herein, black TiO2 nanoparticles (B-TiO2 NPs) with crystal-amorphous core-shell structure are successfully developed. Remarkable SERS activity is derived from the synergistic effect of the promising crystal-amorphous core-shell structure. Abundant excitons can be generated by high-efficiency exciton transitions in the crystal core, a feature that provides sufficient charge source. Significantly, the novel crystal-amorphous heterojunction enables the efficient exciton separation at the crystal-amorphous interface, which can effectively facilitate charge transfer from the crystal core to the amorphous shell and results in exciton enrichment at the amorphous shell. Kelvin probe force microscopy (KPFM) confirms the Fermi level of the amorphous layer shifting to a relatively low position compared to that of the crystal core, allowing efficient photoinduced charge transfer (PICT) between the amorphous shell and probe molecules. The first-principles density functional theory (DFT) calculations further indicate that the amorphous shell structure possesses a narrow band gap and a relatively high electronic density of state (DOS), which can effectively promote vibration coupling with target molecules. Moreover, MCF-7 drug-resistant (MCF-7/ADR) breast cancer cells can be quickly and accurately diagnosed based on the high-sensitivity B-TiO2-based SERS bioprobe. To the best of our knowledge, this is the first time the crystal-amorphous core-shell heterojunction enhancement of the TiO2-molecule PICT process, which widens the application of semiconductor-based SERS platforms in precision diagnosis and treatment of cancer, has been investigated.
学科主题	Science & Technology - Other Topics ; Materials Science
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/20121]
专题	2020专题
作者单位	1.Wu, AG (corresponding author), Chinese Acad Sci, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo Inst Mat Technol & Engn, 1219 ZhongGuan West Rd, Ningbo 315201, Peoples R China. 2.Wu, AG (corresponding author), Chinese Acad Sci, Key Lab Magnet Mat & Devices, Cixi Inst Biomed Engn, 1219 ZhongGuan West Rd, Ningbo 315201, Peoples R China. 3.Wang, XT (corresponding author), Beihang Univ, Minist Educ, Sch Chem & Environm, Key Lab BioInspired Smart Interfacial Sci, Beijing 100191, Peoples R China.
推荐引用方式 GB/T 7714	Lin, Jie,Ren, Wenzhi,Li, Anran,et al. Crystal-Amorphous Core-Shell Structure Synergistically Enabling TiO2 Nanoparticles' Remarkable SERS Sensitivity for Cancer Cell Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12(4):4204-4211.
APA	Lin, Jie.,Ren, Wenzhi.,Li, Anran.,Yao, Chenyang.,Chen, Tianxiang.,...&Wu, Aiguo.(2020).Crystal-Amorphous Core-Shell Structure Synergistically Enabling TiO2 Nanoparticles' Remarkable SERS Sensitivity for Cancer Cell Imaging.ACS APPLIED MATERIALS & INTERFACES,12(4),4204-4211.
MLA	Lin, Jie,et al."Crystal-Amorphous Core-Shell Structure Synergistically Enabling TiO2 Nanoparticles' Remarkable SERS Sensitivity for Cancer Cell Imaging".ACS APPLIED MATERIALS & INTERFACES 12.4(2020):4204-4211.