Separative extended-gate AlGaAs/GaAs HEMT biosensors based on capacitance change strategy

doi:10.1063/5.0001786

CORC > 宁波材料技术与工程研究所 > 中国科学院宁波材料技术与工程研究所 > 2020专题

	Separative extended-gate AlGaAs/GaAs HEMT biosensors based on capacitance change strategy
	Yu, Jiahuan ; Xu, Mengke ; Liang, Lingyan ; Guan, Min ; Zhang, Yang ; Yan, Feng ; Cao, Hongtao
刊名	APPLIED PHYSICS LETTERS
	2020
卷号	116 期号:12
关键词	FIELD-EFFECT TRANSISTORS LABEL-FREE CHANNEL
DOI	10.1063/5.0001786
英文摘要	Separative extended-gate AlGaAs/GaAs high electron mobility transistor (HEMT) biosensors based on the capacitance change strategy are proposed and fabricated. The working mechanism underlying this strategy is clearly clarified via examining the capacitance evolution on biorecognition and the capacitance matching issue between the HEMT and the sensing pad. The fabricated biosensors demonstrate a good linear current/voltage response to a label-free prostate-specific antigen (PSA) target over a broad concentration range of 100 fg/ml to 10ng/ml in both 0.1x and 1x phosphate buffered saline solutions. Specifically, the sensitivity variation approaches 8.7% dec(-1) at the critical concentration level of 2-8ng/ml that enters the normal PSA region in the human body. The advantages of high sensitivity, low-cost, and convenience of usage make the proposed HEMT biosensors potential candidates for prostate cancer diagnosis.
学科主题	Physics
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/19859]
专题	2020专题
作者单位	1.Liang, LY (corresponding author), Chinese Acad Sci, Div Funct Mat & Nano Devices, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Peoples R China. 2.Zhang, Y (corresponding author), Chinese Acad Sci, Key Lab Semicond Mat Sci, Beijing Key Lab Low Dimens Semicond Mat & Devices, Inst Semicond, Beijing 100083, Peoples R China. 3.Guan, M
推荐引用方式 GB/T 7714	Yu, Jiahuan,Xu, Mengke,Liang, Lingyan,et al. Separative extended-gate AlGaAs/GaAs HEMT biosensors based on capacitance change strategy[J]. APPLIED PHYSICS LETTERS,2020,116(12).
APA	Yu, Jiahuan.,Xu, Mengke.,Liang, Lingyan.,Guan, Min.,Zhang, Yang.,...&Cao, Hongtao.(2020).Separative extended-gate AlGaAs/GaAs HEMT biosensors based on capacitance change strategy.APPLIED PHYSICS LETTERS,116(12).
MLA	Yu, Jiahuan,et al."Separative extended-gate AlGaAs/GaAs HEMT biosensors based on capacitance change strategy".APPLIED PHYSICS LETTERS 116.12(2020).