Low LEF1 expression is a biomarker of early T-cell precursor, an aggressive subtype of T-cell lymphoblastic leukemia

doi:10.1371/journal.pone.0232520

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	Low LEF1 expression is a biomarker of early T-cell precursor, an aggressive subtype of T-cell lymphoblastic leukemia
	Wang, Mei 2; Zhang, Chi 1
刊名	PLOS ONE
	2020-05-13
卷号	15 期号:5 页码:9
ISSN号	1932-6203
DOI	10.1371/journal.pone.0232520
英文摘要	Early T-cell precursor (ETP) is the only subtype of acute T-cell lymphoblastic leukemia (T-ALL) listed in the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia. Patients with ETP tend to have worse disease outcomes. ETP is defined by a series of immune markers. The diagnosis of ETP status can be vague due to the limitation of the current measurement. In this study, we performed unsupervised clustering and supervised prediction to investigate whether a molecular biomarker can be used to identify the ETP status in order to stratify risk groups. We found that the ETP status can be predicted by the expression level of Lymphoid enhancer binding factor 1 (LEF1) with high accuracy (AUC of ROC = 0.957 and 0.933 in two T-ALL cohorts). The patients with ETP subtype have a lower level of LEF1 comparing to the those without ETP. We suggest that incorporating the biomarker LEF1 with traditional immune-phenotyping will improve the diagnosis of ETP.
资助项目	Strategic Priority Research Program of Chinese Academy of Sciences[XDB26000000] ; 100 Young Talents Program of Chinese Academy of Sciences ; National Natural Science Foundation of China[81900155]
WOS关键词	WORLD-HEALTH-ORGANIZATION ; MYELOID NEOPLASMS ; CLASS DISCOVERY ; CLASSIFICATION ; REVISION ; MODELS ; TCF-1
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	PUBLIC LIBRARY SCIENCE
WOS记录号	WOS:000537481000019
内容类型	期刊论文
源URL	[http://119.78.100.205/handle/311034/17544]
专题	古脊椎动物与古人类研究所_图书馆1
通讯作者	Wang, Mei
作者单位	1.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Beijing, Peoples R China 2.Peking Univ, Sch Life Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Mei,Zhang, Chi. Low LEF1 expression is a biomarker of early T-cell precursor, an aggressive subtype of T-cell lymphoblastic leukemia[J]. PLOS ONE,2020,15(5):9.
APA	Wang, Mei,&Zhang, Chi.(2020).Low LEF1 expression is a biomarker of early T-cell precursor, an aggressive subtype of T-cell lymphoblastic leukemia.PLOS ONE,15(5),9.
MLA	Wang, Mei,et al."Low LEF1 expression is a biomarker of early T-cell precursor, an aggressive subtype of T-cell lymphoblastic leukemia".PLOS ONE 15.5(2020):9.