Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening

doi:10.1186/s12938-021-00889-1

	Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening
	Ni,Jingshu 4,5; Hong,Haiou 7; Zhang,Yang 4,5; Tang,Shiqi 1; Han,Yongsheng 3; Fang,Zhaohui 2; Zhang,Yuanzhi 4,6; Zhou,Nan 4,6; Wang,Quanfu 4,6; Liu,Yong 4,5,6
刊名	BioMedical Engineering OnLine
	2021-06-01
卷号	20
关键词	Non-invasive Skin cholesterol Absorption spectroscopy Subclinical atherosclerosis
DOI	10.1186/s12938-021-00889-1
通讯作者	Wang,YiKun(wyk@aiofm.ac.cn) ; Dong,Meili(dongmeili@aiofm.ac.cn)
英文摘要	AbstractBackgroundEstablishing a high-accuracy and non-invasive method is essential for evaluating cardiovascular disease. Skin cholesterol is a novel marker for assessing the risk of atherosclerosis and can be used as an independent risk factor of early assessment of atherosclerotic risk.MethodsWe propose a non-invasive skin cholesterol detection method based on absorption spectroscopy. Detection reagents specifically bind to skin cholesterol and react with indicator to produce colored products, the skin cholesterol content can be obtained through absorption spectrum information on colored products detected by non-invasive technology. Gas chromatography is used to measure cholesterol extracted from the skin to verify the accuracy and reliability of the non-invasive test method. A total of 342 subjects were divided into normal group (n?=?115), disease group (n?=?110) and risk group (n?=?117). All subjects underwent non-invasive skin cholesterol test. The diagnostic accuracy of the measured value was analyzed by receiver-operating characteristic (ROC) curve.ResultsThe proposed method is able to identify porcine skin containing gradient concentration of cholesterol. The values measured by non-invasive detection method were significantly correlated with gas chromatography measured results (r?=?0.9074, n?=?73, p?
语种	英语
出版者	BioMed Central
WOS记录号	BMC:10.1186/S12938-021-00889-1
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/122289]
专题	中国科学院合肥物质科学研究院
通讯作者	Wang,YiKun; Dong,Meili
作者单位	1.Renmin Hospital of WuHan University; Health Management Center 2.The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine; Department of Endocrinology 3.First Affiliated Hospital of University of Science and Technology of China; Department of Cardiovascular Medicine 4.Chinese Academy of Sciences; Anhui Provincial Engineering Technology Research Center for Biomedical Optical Instrument, Anhui Institute of Optics and Fine Mechanics, Hefei Institutes of Physical Science 5.University of Science and Technology of China 6.Wanjiang Center for Development of Emerging Industrial Technology 7.First Affiliated Hospital of University of Science and Technology of China; Health Management Center
推荐引用方式 GB/T 7714	Ni,Jingshu,Hong,Haiou,Zhang,Yang,et al. Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening[J]. BioMedical Engineering OnLine,2021,20.
APA	Ni,Jingshu.,Hong,Haiou.,Zhang,Yang.,Tang,Shiqi.,Han,Yongsheng.,...&Dong,Meili.(2021).Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening.BioMedical Engineering OnLine,20.
MLA	Ni,Jingshu,et al."Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening".BioMedical Engineering OnLine 20(2021).