DNA hydrogel-based gene editing and drug delivery systems

doi:10.1016/j.addr.2020.07.018

	DNA hydrogel-based gene editing and drug delivery systems
	Mo, Fangli 1; Jiang, Kai 1; Zhao, Di 1; Wang, Yuqi 1; Song, Jie 1,2; Tan, Weihong 2
刊名	ADVANCED DRUG DELIVERY REVIEWS
	2021
卷号	168
关键词	DNA hydrogels Stimuli responsiveness Drug delivery Biomacromolecules Gene therapy
ISSN号	0169-409X
DOI	10.1016/j.addr.2020.07.018
通讯作者	Song, Jie(sjie@sjtu.edu.cn) ; Tan, Weihong(tan@hnu.edu.cn)
英文摘要	Deoxyribonucleic acid (DNA) is a promising synthesizer for precisely constructing almost arbitrary geometry in two and three dimensions. Among various DNA-based soft materials, DNA hydrogels are comprised of hydrophilic polymeric networks of crosslinked DNA chains. For their properties of biocompatibility, porosity, sequence programmability and tunable multifunctionality, DNA hydrogels have been widely studied in bioanalysis and biomedicine. In this review, recent developments in DNA hydrogels and their applications in drug delivery systems are highlighted. First, physical and chemical crosslinking methods for constructing DNA hydrogels are introduced. Subsequently, responses of DNA hydrogels to nonbiological and biological stimuli are described. Finally, DNA hydrogel-based delivery platforms for different types of drugs are detailed. With the emergence of gene therapy, this review also gives future prospects for combining DNA hydrogels with the gene editing toolbox. (c) 2020 Elsevier B.V. All rights reserved.
资助项目	National Natural Science Foundation of China[81822024] ; National Natural Science Foundation of China[11761141006] ; National Natural Science Foundation of China[21605102] ; National Key Research and Development Program of China[2017YFC1200904] ; Natural Science Foundation of Shanghai[19520714100] ; Natural Science Foundation of Shanghai[19ZR1475800]
WOS关键词	APTAMER-FUNCTIONALIZED HYDROGEL ; CROSS-LINKED HYDROGEL ; ACUTE KIDNEY INJURY ; QUANTUM DOTS ; RNA INTERFERENCE ; BIOMEDICAL APPLICATIONS ; RESPONSIVE HYDROGELS ; EFFICIENT DELIVERY ; CO-DELIVERY ; IN-VITRO
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000612867300005
资助机构	National Natural Science Foundation of China ; National Key Research and Development Program of China ; Natural Science Foundation of Shanghai
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/120288]
专题	中国科学院合肥物质科学研究院
通讯作者	Song, Jie; Tan, Weihong
作者单位	1.Shanghai Jiao Tong Univ, Inst Nano Biomed & Engn, Sch Elect Informat & Elect Engn, Dept Instrument Sci & Engn, Shanghai 200240, Peoples R China 2.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Canc & Basic Med IBMC, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Mo, Fangli,Jiang, Kai,Zhao, Di,et al. DNA hydrogel-based gene editing and drug delivery systems[J]. ADVANCED DRUG DELIVERY REVIEWS,2021,168.
APA	Mo, Fangli,Jiang, Kai,Zhao, Di,Wang, Yuqi,Song, Jie,&Tan, Weihong.(2021).DNA hydrogel-based gene editing and drug delivery systems.ADVANCED DRUG DELIVERY REVIEWS,168.
MLA	Mo, Fangli,et al."DNA hydrogel-based gene editing and drug delivery systems".ADVANCED DRUG DELIVERY REVIEWS 168(2021).