Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress

doi:10.1016/j.mce.2020.111144

	Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress
	Wen, Qing-Liang 1,2,3; Yi, He-Qing 1,2,3; Yang, Ke 1,2,3; Yin, Chang-Tian 4; Yin, Wen-Juan 1,2,3; Xiang, Fang-Yue 5; Bao, Miao 6; Shuai, Jing 5; Song, Yi-Wei 5; Ge, Ming-Hua 4
刊名	MOLECULAR AND CELLULAR ENDOCRINOLOGY
	2021-03-01
卷号	523
关键词	Papillary thyroid carcinoma PIM-1 Oxidative stress NOX4
ISSN号	0303-7207
DOI	10.1016/j.mce.2020.111144
通讯作者	Ge, Ming-Hua(geminghua@hmc.edu.cn) ; Zhu, Xin(zhuxin@zjcc.org.cn)
英文摘要	In this study, we aimed to clarify the role of PIM-1 in papillary thyroid carcinoma (PTC) in vitro and investigate the relationship between PIM-1 and redox proteins (NOX4, SOD2, and GPX2) at the tissue and cellular levels. As a PIM-1 inhibitor, SGI-1776 inhibited cell proliferation, colony formation, migration and induced an increase in apoptosis and reactive oxygen species in two PTC cell lines (BCPAP and TPC-1). The expressions of PIM-1, SOD2 and GPX2 were downregulated after siNOX4 exposure. Immunohistochemistry in 120 PTC patients showed that all four proteins exhibited higher expression levels in PTC tissues than in adjacent normal tissues. PIM-1 expression was related to NOX4, SOD2, and GPX2 expressions. The Cancer Genome Atlas database analysis showed the significant correlation between the expression of NOX4 and PIM-1. Our results demonstrated that PIM-1 played an important oncogenic role in PTC carcinogenesis that may be related to oxidative stress.
资助项目	National Natural Science Foundation of China[82072950] ; Zhejiang Province Natural Science Foundation of China[LY17H070003] ; Zhejiang Province Natural Science Foundation of China[LY20H180007]
WOS研究方向	Cell Biology ; Endocrinology & Metabolism
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000614236500006
资助机构	National Natural Science Foundation of China ; Zhejiang Province Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/119651]
专题	中国科学院合肥物质科学研究院
通讯作者	Ge, Ming-Hua; Zhu, Xin
作者单位	1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou, Peoples R China 2.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China 3.Key Lab Head & Neck Canc Translat Res Zhejiang Pr, Hangzhou, Peoples R China 4.Zhejiang Prov Peoples Hosp, Dept Head & Neck Surg, Hangzhou, Peoples R China 5.Zhejiang Chinese Med Univ, Stomatol Coll, Hangzhou, Peoples R China 6.Zhejiang Univ, Affiliated Jinhua Hosp, Sch Med, Jinhua, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Wen, Qing-Liang,Yi, He-Qing,Yang, Ke,et al. Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress[J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY,2021,523.
APA	Wen, Qing-Liang.,Yi, He-Qing.,Yang, Ke.,Yin, Chang-Tian.,Yin, Wen-Juan.,...&Zhu, Xin.(2021).Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress.MOLECULAR AND CELLULAR ENDOCRINOLOGY,523.
MLA	Wen, Qing-Liang,et al."Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress".MOLECULAR AND CELLULAR ENDOCRINOLOGY 523(2021).