Cardio-protection of ultrafine granular powder for Salvia miltiorrhiza Bunge against myocardial infarction

doi:10.1016/j.jep.2018.04.029

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	Cardio-protection of ultrafine granular powder for Salvia miltiorrhiza Bunge against myocardial infarction
	Wang, Linlin 2; Li, Yuanmin 2; Deng, Wen 3; Dong, Zhihui 4; Li, Xue 2; Liu, Dan 2; Zhao, Lijie 2; Fu, Weiguo 4; Cho, Kenka 1; Niu, Huaying 5
刊名	JOURNAL OF ETHNOPHARMACOLOGY
	2018-08-10
卷号	222 页码:99-106
关键词	Ultrafine granular powder Traditional herbal decoction Salvia miltiorrhiza Bunge Myocardial infarction Cardio-protection
ISSN号	0378-8741
DOI	10.1016/j.jep.2018.04.029
文献子类	Article
英文摘要	Ethnopharmacological relevance: Myocardial infarction (MI) is considered as the major inducer to the morbidity and mortality related to coronary occlusion. Salvia miltiorrhiza Bunge is widely applied in the clinic for the. prevention and treatment of heart diseases. The preparation of traditional herb decoction (THD) is not only time consuming but also difficult to keep uniform for every time. New usage form of Salvia miltiorrhiza Bunge with characteristics of convenience, uniform and efficiency is needed. Aim of the study: The aims of present study were to investigate the cardio-protection of ultrafine granular powder (UGP) of Salvia miltiorrhiza Bunge; and further compare the characteristics of UGP with THD. Materials and methods: MI was induced by ligation of the left anterior descending coronary artery near the main pulmonary artery. Cardio-protection of UGP or THD was evaluated based on two sets of experiments, one was acute myocardial infarction (AMI) through 7 days preventive administration, and the other one was chronic cardiac remodeling through 28 days therapeutic administration. Hemodynamic measurement was conducted to evaluate heart function and histopathological detection was used to evaluate heart structure. Results: No significant improvement of heart structure and function was detected for preventive administration of UGP or THD on AMI rats. While, more significant improvements on left ventricular systolic and diastolic function were detected with therapeutic treatment with 0.81 g/kg UGP than same dose of THD on rats against chronic cardiac remodeling. Both UGP and THD showed the protective effects on heart structure, especially against fibrosis with long-term therapeutic treatment. Conclusions: As a new usage form of Salvia miltiorrhiza Bunge, UGP showed significant cardio-protection against myocardial remodeling with therapeutic treatment. Comparing with THD, UGP also holds the advantages of uniform, convenience and efficiency.
资助项目	Shanghai Science and Technology Development Foundation[16401901800] ; Bureau of Science and Technology for Development Chinese Academy of Sciences[ZSTH-011] ; National Natural Science Foundation of China[81573646]
WOS关键词	HEART-FAILURE ; DANSHEN ; BIOAVAILABILITY ; PATHWAY ; DISEASE
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000436224700010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279621]
专题	上海中药现代化研究中心
通讯作者	Cheng, Jinle; Jiang, Baohong
作者单位	1.Takarazuka Univ Med & Hlth Care, Takarazuka, Hyogo, Japan; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China; 3.State Adm Tradit Chinese Med, Key Lab Technol & Applicat Ultrafine Granular Pow, Guangzhou, Guangdong, Peoples R China; 4.Fudan Univ, Zhongshan Hosp, Dept Vasc Surg, Shanghai, Peoples R China; 5.Dachpharm Dev Co Ltd, Jinan, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Wang, Linlin,Li, Yuanmin,Deng, Wen,et al. Cardio-protection of ultrafine granular powder for Salvia miltiorrhiza Bunge against myocardial infarction[J]. JOURNAL OF ETHNOPHARMACOLOGY,2018,222:99-106.
APA	Wang, Linlin.,Li, Yuanmin.,Deng, Wen.,Dong, Zhihui.,Li, Xue.,...&Jiang, Baohong.(2018).Cardio-protection of ultrafine granular powder for Salvia miltiorrhiza Bunge against myocardial infarction.JOURNAL OF ETHNOPHARMACOLOGY,222,99-106.
MLA	Wang, Linlin,et al."Cardio-protection of ultrafine granular powder for Salvia miltiorrhiza Bunge against myocardial infarction".JOURNAL OF ETHNOPHARMACOLOGY 222(2018):99-106.