Activation of AhR with nuclear IKK alpha regulates cancer stem-like properties in the occurrence of radioresistance

doi:10.1038/s41419-018-0542-9

	Activation of AhR with nuclear IKK alpha regulates cancer stem-like properties in the occurrence of radioresistance
	Yan, Bin 1,2,6; Liu, Shuang 1,2; Shi, Ying 2,6; Liu, Na 2,6; Chen, Ling 2,6; Wang, Xiang 12; Xiao, Desheng 3; Liu, Xiaoli 2,6; Mao, Chao 2,6; Jiang, Yiqun 2,6
刊名	CELL DEATH & DISEASE
	2018-04-30
卷号	9
ISSN号	2041-4889
DOI	10.1038/s41419-018-0542-9
文献子类	Article
英文摘要	Most cancer patients receive radiotherapy in the course of their disease and the occurrence of radioresistance is associated with poor prognosis. The molecular pathways that drive enhanced tumorigenic potential during the development of radioresistance are poorly understood. Here, we demonstrate that aryl hydrocarbon receptor (AhR) plays a vital role in the maintenance of cancer stem-like properties. AhR promotes the cancer stem-like phenotype and drives metastasis by directly targeting the promoters of 'stemness' genes, such as the ATP-binding cassette sub-family G member 2 (ABCG2) gene. Moreover, the radioresistant sublines display high levels of oncometabolites including alpha-ketoglutarate, and treatment of cancer cells with alpha-ketoglutarate enhances their stem-like properties in an AhR activation-dependent manner. IKK alpha directly activates stemness-related genes through an interaction with AhR as a bone fide chromatin modifier. Thus, AhR is functionally linked with cancer stem-like properties, and it drives tumorigenesis in the occurrence of radioresistance.
资助项目	National Basic Research Program of China[2015CB553903] ; National Natural Science Foundation of China[81672787] ; National Natural Science Foundation of China[81372427] ; National Natural Science Foundation of China[81672991] ; National Natural Science Foundation of China[81271763] ; National Natural Science Foundation of China[81302354] ; National Natural Science Foundation of China[81422051] ; National Natural Science Foundation of China[81472593] ; Fundamental Research Funds for the Central Universities[2013ZZTS074] ; Frederick National Laboratory for Cancer Research[00000000] ; National Institutes of Health[HHSN261200800001E]
WOS关键词	ARYL-HYDROCARBON RECEPTOR ; NF-KAPPA-B ; EPITHELIAL-MESENCHYMAL TRANSITION ; SQUAMOUS-CELL CARCINOMA ; TUMOR-INITIATING CELLS ; REMODELING FACTOR LSH ; METASTASIS ; ONCOMETABOLITE ; EXPRESSION ; LIGANDS
WOS研究方向	Cell Biology
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000431785900001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279791]
专题	分析化学研究室
通讯作者	Liu, Shuang; Tao, Yongguang
作者单位	1.Cent S Univ, Xiangya Hosp, Inst Med Sci, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China; 2.Cent S Univ, Xiangya Hosp, Minist Educ, Key Lab Carcinogenesis & Canc Invas, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China; 3.Cent S Univ, Xiangya Hosp, Dept Pathol, Changsha 410008, Hunan, Peoples R China; 4.Univ South China, Peoples Hosp Chenzhou 1, Translat Med Inst, Natl & Local Joint Engn Lab High Throughput Mol D, 102 Luojiajing Rd, Chenzhou 423000, Hunan, Peoples R China; 5.Changzhi Med Coll, Dept Pathophysiol, Changzhi, Shanxi, Peoples R China; 6.Cent S Univ, Canc Res Inst, 110 Xiangya Rd, Changsha 410078, Hunan, Peoples R China; 7.Cent S Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410078, Hunan, Peoples R China; 8.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Chongzhi Rd,Zhangjiang Hi Tech Pk, Shanghai 201203, Peoples R China; 9.Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, Changsha 410078, Hunan, Peoples R China; 10.Cipher Gene Beijing Co Ltd, Beijing 100089, Peoples R China;
推荐引用方式 GB/T 7714	Yan, Bin,Liu, Shuang,Shi, Ying,et al. Activation of AhR with nuclear IKK alpha regulates cancer stem-like properties in the occurrence of radioresistance[J]. CELL DEATH & DISEASE,2018,9.
APA	Yan, Bin.,Liu, Shuang.,Shi, Ying.,Liu, Na.,Chen, Ling.,...&Tao, Yongguang.(2018).Activation of AhR with nuclear IKK alpha regulates cancer stem-like properties in the occurrence of radioresistance.CELL DEATH & DISEASE,9.
MLA	Yan, Bin,et al."Activation of AhR with nuclear IKK alpha regulates cancer stem-like properties in the occurrence of radioresistance".CELL DEATH & DISEASE 9(2018).