Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis

doi:10.1002/adfm.201801840

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis
	Zhang, Zhiwen1,3 ; Wang, Hong 1,3; Tan, Tao 1,3; Li, Jie 1,3; Wang, Zhiwan 1,3; Li, Yaping1,2,3
刊名	ADVANCED FUNCTIONAL MATERIALS
	2018-10-04
卷号	28 期号:40
关键词	drug delivery metastasis nanoparticles penetration tumors
ISSN号	1616-301X
DOI	10.1002/adfm.201801840
文献子类	Review
英文摘要	The limited penetration of nanoparticles in primary tumors and metastases remains a great challenge for effective treatment of tumor metastasis. This review outlines the current approaches and summarizes the rational design of nanoparticles with deep tumor penetration capacity for anti-metastasis treatment. There are two ways to achieve better tumor penetration; through rational regulation of the physicochemical properties of nanoparticles and through remodeling of the tumor microenvironment, including the tumor vasculature and stromal environment. Moreover, biomimetic strategies that integrate the advantages of nanoparticles and metastasis-homing molecules during cancer cell metastasis are discussed. These efforts have led to promising results in facilitating intratumoral permeation of various nanoparticles to enhance antitumor effects. The considerations and some feasible future directions for deep tumor penetration strategies are proposed to improve tumor metastasis therapies.
资助项目	National Basic Research Program of China[2015CB932103] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; Youth Innovation Promotion Association of CAS[00000000]
WOS关键词	MESENCHYMAL STEM-CELLS ; TARGETED DRUG-DELIVERY ; GUIDED PHOTOTHERMAL THERAPY ; COMBINATION CANCER-THERAPY ; LUNG MELANOMA METASTASES ; BREAST-CANCER ; IN-VIVO ; SOLID TUMORS ; POLYMERIC MICELLES ; EXTRACELLULAR-MATRIX
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000446155700004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279542]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Zhang, Zhiwen; Li, Yaping
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Yantai Univ, Sch Pharm, Yantai 264005, Shandong, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Zhang, Zhiwen,Wang, Hong,Tan, Tao,et al. Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(40).
APA	Zhang, Zhiwen,Wang, Hong,Tan, Tao,Li, Jie,Wang, Zhiwan,&Li, Yaping.(2018).Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis.ADVANCED FUNCTIONAL MATERIALS,28(40).
MLA	Zhang, Zhiwen,et al."Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis".ADVANCED FUNCTIONAL MATERIALS 28.40(2018).