Beneficial effect of resveratrol on α‑naphthyl isothiocyanate‑induced cholestasis via regulation of the FXR pathway

doi:10.3892/mmr.2017.8051

	Beneficial effect of resveratrol on α‑naphthyl isothiocyanate‑induced cholestasis via regulation of the FXR pathway
	Ding, Lili; Zhang, Binfeng; Li, Jinmei; Yang, Li; Wang, Zhengtao
刊名	Molecular medicine reports
	2018-01
卷号	17 期号:1 页码:1863-1872
ISSN号	1791-3004
DOI	10.3892/mmr.2017.8051
文献子类	Article
英文摘要	Cholestasis is defined as a functional impairment of bile secretion which results in the accumulation of bile acids (BAs) and other toxic molecules in the blood and liver, however, there are very few effective therapies for cholestasis. The farnesoid X receptor (FXR), as a nuclear receptor for BAs, is important in the regulation of BA levels in enterohepatic circulation. It has previously been demonstrated that activation of the FXR pathway may be a useful strategy with which to treat cholestasis. Resveratrol, one of the important ingredients from grape skins and Chinese medicine Polygonum cuspidatum, resulted in FXR‑activated effects in vitro and exhibited a protective effect against α‑naphthylisothiocyanate (ANIT)‑induced cholestasis through FXR regulation in vivo. The underlying mechanisms of resveratrol against ANIT‑induced cholestasis may be due to the regulation of BA homeostasis, improvement of liver injury and attenuation of the inflammatory response, which were regulated in a FXR‑dependent manner and in turn contributed to overall cholestasis alleviation. Overall, resveratrol as a FXR agonist may act as a potential compound for the treatment of drug‑induced cholestasis.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266394]
专题	中国科学院上海药物研究所
作者单位	Shanghai Key Laboratory of Compound Chinese Medicines and The Ministry of Education Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China
推荐引用方式 GB/T 7714	Ding, Lili,Zhang, Binfeng,Li, Jinmei,et al. Beneficial effect of resveratrol on α‑naphthyl isothiocyanate‑induced cholestasis via regulation of the FXR pathway[J]. Molecular medicine reports,2018,17(1):1863-1872.
APA	Ding, Lili,Zhang, Binfeng,Li, Jinmei,Yang, Li,&Wang, Zhengtao.(2018).Beneficial effect of resveratrol on α‑naphthyl isothiocyanate‑induced cholestasis via regulation of the FXR pathway.Molecular medicine reports,17(1),1863-1872.
MLA	Ding, Lili,et al."Beneficial effect of resveratrol on α‑naphthyl isothiocyanate‑induced cholestasis via regulation of the FXR pathway".Molecular medicine reports 17.1(2018):1863-1872.