hierarchicalactivationofcompartmentalizedpoolsofampkdependsonseverityofnutrientorenergystress

	hierarchicalactivationofcompartmentalizedpoolsofampkdependsonseverityofnutrientorenergystress
	Yue Zong 1; ChenSong Zhang 1; Mengqi Li 1; Wen Wang 2; Zhichao Wang 2; Simon A Hawley 4; Teng Ma 1; JinWei Feng 1; Xiao Tian 1; Qu Qi 1
刊名	细胞研究英文版
	2019-01-01
卷号	029 期号:006 页码:460
ISSN号	1001-0602
英文摘要	AMPK, a master regulator of metabolic homeostasis, is activated by both AMP-dependent and AMP-independent mechanisms. The conditions under which these different mechanisms operate, and their biological implications are unclear. Here, we show that, depending on the degree of elevation of cellular AMP, distinct compartmentalized pools of AMPK are activated, phosphorylating different sets of targets. Low glucose activates AMPK exclusively through the AMP-independent, AXIN-based pathway in lysosomes to phosphorylate targets such as ACC1 and SREBP1c, exerting early anti-anabolic and pro-catabolic roles. Moderate increases in AMP expand this to activate cytosolic AMPK also in an AXIN-dependent manner. In contrast, high concentrations of AMP, arising from severe nutrient stress, activate all pools of AMPK independently of AXIN. Surprisingly, mitochondrion-localized AMPK is activated to phosphorylate ACC2 and mitochondrial fission factor (MFF) only during severe nutrient stress. Our findings reveal a spatiotemporal basis for hierarchical activation of different pools of AMPK during differing degrees of stress severity.
资助项目	[National Key R&D Program of China] ; [National Natural Science Foundation of China] ; [Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University] ; [Wellcome Trust]
语种	英语
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/175257]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.厦门大学 2.中国科学院大连化学物理研究所 3.中国科学院大学 4.邓迪大学
推荐引用方式 GB/T 7714	Yue Zong,ChenSong Zhang,Mengqi Li,et al. hierarchicalactivationofcompartmentalizedpoolsofampkdependsonseverityofnutrientorenergystress[J]. 细胞研究英文版,2019,029(006):460.
APA	Yue Zong.,ChenSong Zhang.,Mengqi Li.,Wen Wang.,Zhichao Wang.,...&ShengCai Lin.(2019).hierarchicalactivationofcompartmentalizedpoolsofampkdependsonseverityofnutrientorenergystress.细胞研究英文版,029(006),460.
MLA	Yue Zong,et al."hierarchicalactivationofcompartmentalizedpoolsofampkdependsonseverityofnutrientorenergystress".细胞研究英文版 029.006(2019):460.