Enhanced contextual fear memory in central serotonin-deficient mice | |
Dai, Jin-Xia ; Han, Hui-Li ; Tian, Meng ; Cao, Jun ; Xiu, Jian-Bo ; Song, Ning-Ning ; Huang, Ying ; Xu, Tian-Le(徐天乐) ; Ding, Yu-Qiang ; Xu, Lin | |
刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
2008 | |
卷号 | 105期号:33页码:11981-11986 |
关键词 | hippocampus long-term depression long-term potentiation anxiety LONG-TERM POTENTIATION SYNAPTIC PLASTICITY HIPPOCAMPAL NEUROGENESIS MAJOR DEPRESSION IN-VIVO STRESS RAT SYSTEM ANXIETY BRAIN |
ISSN号 | 0027-8424 |
通讯作者 | Ding, YQ (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China,dingyq@ion.ac.cn |
英文摘要 | Central serotonin (5-HT) dysregulation contributes to the susceptibility for mental disorders, including depression, anxiety, and posttraumatic stress disorder, and learning and memory deficits. We report that the formation of hippocampus-dependent spatial memory is compromised, but the acquisition and retrieval of contextual fear memory are enhanced, in central 5-HT-deficient mice. Genetic deletion of serotonin in the brain was achieved by inactivating Lmx1b selectively in the raphe nuclei of the brainstem, resulting in a near-complete loss of 5-HT throughout the brain. These 5-HT-deficient mice exhibited no gross abnormality in brain structures and had normal locomotor activity. Spatial learning in the Morris water maze was unaffected, but the retrieval of spatial memory was impaired. In contrast, contextual fear learning and memory induced by foot-shock conditioning was markedly enhanced, but this enhancement could be prevented by intracerebroventricular administration of 5-HT. Foot shock impaired long-term potentiation and facilitated long-term depression in hippocampal slices in WT mice but had no effect in 5-HT-deficient mice. Furthermore, bath application of 5-HT in 5-HT-deficient mice restored foot shock-induced alterations of hippocampal synaptic plasticity. Thus, central 5-HT regulates hippocampus-dependent contextual fear memory, and 5-HT modulation of hippocampal synaptic plasticity may be the underlying mechanism. The enhanced fear memory in 5-HT-deficient mice supports the notion that 5-HT deficiency confers susceptibility to posttraumatic stress disorder in humans. |
学科主题 | Science & Technology - Other Topics |
收录类别 | SCI |
资助信息 | National Natural Science Foundation of China[30721004, 30525014, 30570637, 30530250, 30470549]; Ministry of Science and Technology of China[2006CB806601, 2006CB500808, 2007CB512303]; "Pujing Project" of Shanghai, China[06PJ14116]; Chinese Academy of Sciences[KSCX2-YW-R-35, KSCX2-YW-R-100] |
语种 | 英语 |
公开日期 | 2012-07-23 |
内容类型 | 期刊论文 |
源URL | [http://ir.sibs.ac.cn/handle/331001/1702] |
专题 | 上海神经科学研究所_神经所(总) |
推荐引用方式 GB/T 7714 | Dai, Jin-Xia,Han, Hui-Li,Tian, Meng,et al. Enhanced contextual fear memory in central serotonin-deficient mice[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2008,105(33):11981-11986. |
APA | Dai, Jin-Xia.,Han, Hui-Li.,Tian, Meng.,Cao, Jun.,Xiu, Jian-Bo.,...&Xu, Lin.(2008).Enhanced contextual fear memory in central serotonin-deficient mice.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,105(33),11981-11986. |
MLA | Dai, Jin-Xia,et al."Enhanced contextual fear memory in central serotonin-deficient mice".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105.33(2008):11981-11986. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论