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	Diversity of telomere palindromic sequences and replication genes among Streptomyces linear plasmids
	Zhang R. ; Yang Y. ; Fang P. ; Jiang C. L. ; Xu L. H. ; Zhu Y. M. ; Shen M. J. ; Xia H. Y. ; Zhao J. F. ; Chen T. B. ; Qin Z. J.
	2006
关键词	complete genome sequence coelicolor a3(2) dna-replication nucleotide-sequence terminal proteins chromosomes origin lividans scp1 ends
英文摘要	Streptomyces sp. linear plasmids and linear chromosomes usually contain conserved terminal palindromic sequences bound by the conserved telomeric proteins Tap and Tp, encoded by the tap and tpg genes, respectively, as well as plasmid loci required for DNA replication in circular mode when the telomeres are deleted. These consist of iterons and an adjacent rep gene. By using PCR, we found that 8 of 17 newly detected linear plasmids in Streptomyces strains lack typical telomeric tap and tpg sequences. Instead, two novel telomeres in plasmids pRL1 and pRL2 from the eight strains and one conserved telomere in pFRL1 from the other strains were identified, while multiple short palindromes were also found in the plasmids. The complete nucleotide sequence of pRL2 revealed a gene encoding a protein containing two domains, resembling Tap of Streptomyces and a helicase of Thiobacillus, and an adjacent gene encoding a protein similar to Tpg of Streptomyces and a portion of the telomere terminal protein pTP of adenoviruses. No typical iterons-rep loci were found in the three plasmids. These results indicate an unexpected diversity of telomere palindromic sequences and replication genes among Streptomyces linear plasmids.
出处	Applied and Environmental Microbiology
卷	72
期	9
页	5728-5733
收录类别	SCI
语种	英语
ISSN号	0099-2240
内容类型	SCI/SSCI论文
源URL	[http://ir.igsnrr.ac.cn/handle/311030/22379]
专题	地理科学与资源研究所_历年回溯文献
推荐引用方式 GB/T 7714	Zhang R.,Yang Y.,Fang P.,et al. Diversity of telomere palindromic sequences and replication genes among Streptomyces linear plasmids. 2006.

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