When a Semiconductor Utilized as an NIR Laser-Responsive Photodynamic/Photothermal Theranostic Agent Integrates with Upconversion Nanoparticles

doi:10.1021/acsbiomaterials.9b00438

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	When a Semiconductor Utilized as an NIR Laser-Responsive Photodynamic/Photothermal Theranostic Agent Integrates with Upconversion Nanoparticles
	Lv, Ruichan 1; Wang, Yanxing 1; Liu, Jun 1; Feng, Miao 1; Yang, Fan 1; Jiang, Xue 1; Tian, Jie1,2
刊名	ACS BIOMATERIALS SCIENCE & ENGINEERING
	2019-06-01
卷号	5 期号:6 页码:3100-3110
关键词	donor-acceptor lanthanide doped semiconductor photodynamic therapy (PDT)
ISSN号	2373-9878
DOI	10.1021/acsbiomaterials.9b00438
通讯作者	Lv, Ruichan(rclv@xidian.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要	Photoactive theranostics including photodynamic therapy (PDT) hace aroused an intensive interest that combines medical diagnostics with treatment under a single irradiation laser. However, the conventional organic PDT agents usually suffer from aggregation caused by the quenching effect. In this research, we designed a core-shell-shell (CSS) UCNPs with NaGdF4 as the host, and the UCNPs could emit higher blue/green light by the energy transfer processes among Nd/Yb/Tm/Gd/Tb under 808 nm laser. When the CSS UCNPs were combined with the MnO2 semiconductor as the energy acceptor, CSS@Mn could be utilized as an effective PDT agent under a NIR laser. The temperature also increased more than 12.2 degrees C under the 808 nm laser, indicating the potential of synergistic photothermal therapy (PTT) and PDT. Interestingly, cells with small amounts of H2O2 could be responsive to the CSS@Mn platform. The antitumor effect was proved by the in vitro and in vivo experiments. Also, the biocompatibility, biodistribution, and excretion pathway were detected and revealed by the H&E stained pathological section and photoacoustic (PA) images. That means this platform could be potentially used as antitumor PDT/PTT agents.
资助项目	Natural Science Foundation of China[NSFC 81801744] ; Natural Science Foundation of China[81227901] ; National Key R&D Program of China[2017YFA0205202] ; Fundamental Research Funds for the Central Universities[XJS17011] ; Fundamental Research Funds for the Central Universities[JBX181202]
WOS关键词	INFRARED QUANTUM DOTS ; SINGLET OXYGEN ; CANCER-THERAPY ; LIGHT ; NANOCRYSTALS ; DECOMPOSITION ; LUMINESCENCE ; GENERATION ; STRATEGY ; PROGRESS
WOS研究方向	Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000471212300040
资助机构	Natural Science Foundation of China ; National Key R&D Program of China ; Fundamental Research Funds for the Central Universities
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/26024]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Lv, Ruichan; Tian, Jie
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Xian 710071, Shaanxi, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Lv, Ruichan,Wang, Yanxing,Liu, Jun,et al. When a Semiconductor Utilized as an NIR Laser-Responsive Photodynamic/Photothermal Theranostic Agent Integrates with Upconversion Nanoparticles[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2019,5(6):3100-3110.
APA	Lv, Ruichan.,Wang, Yanxing.,Liu, Jun.,Feng, Miao.,Yang, Fan.,...&Tian, Jie.(2019).When a Semiconductor Utilized as an NIR Laser-Responsive Photodynamic/Photothermal Theranostic Agent Integrates with Upconversion Nanoparticles.ACS BIOMATERIALS SCIENCE & ENGINEERING,5(6),3100-3110.
MLA	Lv, Ruichan,et al."When a Semiconductor Utilized as an NIR Laser-Responsive Photodynamic/Photothermal Theranostic Agent Integrates with Upconversion Nanoparticles".ACS BIOMATERIALS SCIENCE & ENGINEERING 5.6(2019):3100-3110.