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	Core-Shell Structurized Fe3O4@C@MnO2 Nanoparticles as pH Responsive T-1-T-2* Dual-Modal Contrast Agents for Tumor Diagnosis
	Duan, Beichen1; Wang, Dongdong1; Wu, Huihui3; Xu, Pengping1; Jiang, Peng1; Xia, Guoliang1; Liu, Zhenbang3; Wang, Haibao4; Guo, Zhen3; Chen, Qianwang1,2
刊名	ACS BIOMATERIALS SCIENCE & ENGINEERING
	2018-08-01
卷号	4期号:8页码:3047-3054
关键词	MRI contrast agent dual-modal pH-responsive Fe3O4@C@MnO2
ISSN号	2373-9878
DOI	10.1021/acsbiomaterials.8b00287
通讯作者	Wang, Haibao(whblgh@mail.ustc.edu.cn) ; Guo, Zhen(zhenguo@ustc.edu.cn) ; Chen, Qianwang(cqw@ustc.edu.cn)
英文摘要	Biocompatible core shell Fe3O4@C@MnO2 nanopartides (named as FOCMO NPs) with an average size at 130 nm prepared through an effortless yet efficient strategy were employed as pH-activatable T-1-T-2* dual-modality magnetic resonance imaging (MRI) contrast agents (CAs). The release rate of Mn ions in acidic PBS (pH = 5.0) was approximately 10 times to that under condition with pH value of 7.4. Benefiting from excellent acid responsiveness, which facilitates the release of ions from FOCMO NPs at tumor region with acidic microenvironment and organelles, the diagnosis accuracy was commendably improved. After intravenous injection of FOCMO NPs, an efficiently intensive contrast in tumors are realized with a distinct enhancement of 127% in T-1 MRI signal 24 h after the administration. Moreover, a significant decreasement of 71% is witnessed in T-2 MRI signal. Those demonstrated that FOCMO NPs can achieve the purpose of positive/negative MRI simultaneously. Furthermore, obtained FOCMO NPs showed great hemocompatibility and negligible toxicity.
资助项目	National Natural Science Foundation of China[21571168] ; Most[2016YFA0101202] ; Most[U1232211] ; Most[31471268] ; National Key R&D Program of China[2016YFA0401801]
WOS关键词	IRON-OXIDE NANOPARTICLES ; IMAGING PROBES ; THERAPY ; HYBRID ; SUPERCAPACITORS ; NANOCRYSTALS ; NANOTUBE ; ALBUMIN ; MN(II) ; T-1
WOS研究方向	Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000441852000035
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/38085]
专题	合肥物质科学研究院_中科院强磁场科学中心
通讯作者	Wang, Haibao; Guo, Zhen; Chen, Qianwang
作者单位	1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Dept Mat Sci & Engn, 96 JinZhai Rd, Hefei 230026, Anhui, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China 3.Univ Sci & Technol China, Anhui Key Lab Cellular Dynam & Chem Biol, Sch Life Sci, 96 JinZhai Rd, Hefei 230027, Anhui, Peoples R China 4.Anhui Med Univ, Affiliated Hosp 1, Radiol Dept, 218 Jixi Rd, Hefei 230022, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Duan, Beichen,Wang, Dongdong,Wu, Huihui,et al. Core-Shell Structurized Fe3O4@C@MnO2 Nanoparticles as pH Responsive T-1-T-2* Dual-Modal Contrast Agents for Tumor Diagnosis[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2018,4(8):3047-3054.
APA	Duan, Beichen.,Wang, Dongdong.,Wu, Huihui.,Xu, Pengping.,Jiang, Peng.,...&Chen, Qianwang.(2018).Core-Shell Structurized Fe3O4@C@MnO2 Nanoparticles as pH Responsive T-1-T-2* Dual-Modal Contrast Agents for Tumor Diagnosis.ACS BIOMATERIALS SCIENCE & ENGINEERING,4(8),3047-3054.
MLA	Duan, Beichen,et al."Core-Shell Structurized Fe3O4@C@MnO2 Nanoparticles as pH Responsive T-1-T-2* Dual-Modal Contrast Agents for Tumor Diagnosis".ACS BIOMATERIALS SCIENCE & ENGINEERING 4.8(2018):3047-3054.

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