Revisiting the impact of OXTR rs53576 on empathy: A population-based   study and a meta-analysis

doi:10.1016/j.psyneuen.2017.03.005

CORC > 北京大学 > 心理与认知科学学院

	Revisiting the impact of OXTR rs53576 on empathy: A population-based study and a meta-analysis
	Gong, Pingyuan ; Fan, Huiyong ; Liu, Jinting ; Yang, Xing ; Zhang, Kejin ; Zhou, Xiaolin
刊名	PSYCHONEUROENDOCRINOLOGY
	2017
关键词	Empathy Oxytocin Polymorphism Association analysis Meta-analysis OXYTOCIN RECEPTOR GENE COGNITIVE EMPATHY CULTURE POLYMORPHISM ASSOCIATION HUMANS MIND REPLICATION COOPERATION RESPONSES
DOI	10.1016/j.psyneuen.2017.03.005
英文摘要	Oxytocin in the brain is related to empathy, which refers to the ability to understand and share others' internal states or responses. Previous studies have investigated the impact of OXTR rs53576, the most intensively examined polymorphism in the oxytocin receptor (OXTR) gene, on individual differences in empathy. However, these studies produced inconsistent results. In the current study, we reexamined the association of OXTR rs53576 with empathy in a relatively large population (N=1830) and also evaluated the association by a comprehensive meta-analysis (N = 6631, 13 independent samples). The replication study indicated that OXTR rs53576 was indeed associated with individual differences in empathy. Individuals with a greater number of G alleles showed better empathic ability, particularly in fantasizing other's feelings and actions. The meta-analysis not only confirmed this association, but also indicated that the impact of this polymorphism was significant in both Europeans and Asians. These findings provide convincing evidence for the impact of OXTR rs53576 on empathy, highlighting the importance of OXTR gene in individuals' social cognition. (C) 2017 Published by Elsevier Ltd.; Natural Science Foundation of China [31640037]; Opening Foundation of Shaanxi Key Laboratory for Animal Conservation (Northwest University); Science Research Foundation of Northwest University [338050067]; SCI(E); SSCI; ARTICLE; 131-136; 80
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/469166]
专题	心理与认知科学学院
推荐引用方式 GB/T 7714	Gong, Pingyuan,Fan, Huiyong,Liu, Jinting,et al. Revisiting the impact of OXTR rs53576 on empathy: A population-based study and a meta-analysis[J]. PSYCHONEUROENDOCRINOLOGY,2017.
APA	Gong, Pingyuan,Fan, Huiyong,Liu, Jinting,Yang, Xing,Zhang, Kejin,&Zhou, Xiaolin.(2017).Revisiting the impact of OXTR rs53576 on empathy: A population-based study and a meta-analysis.PSYCHONEUROENDOCRINOLOGY.
MLA	Gong, Pingyuan,et al."Revisiting the impact of OXTR rs53576 on empathy: A population-based study and a meta-analysis".PSYCHONEUROENDOCRINOLOGY (2017).