Organochlorine pesticide levels inmaternal serumand risk of neural tube   defects in offspring in Shanxi Province, China: A case-control study

doi:10.1016/j.scitotenv.2014.05.075

CORC > 北京大学 > 城市与环境学院

	Organochlorine pesticide levels inmaternal serumand risk of neural tube defects in offspring in Shanxi Province, China: A case-control study
	Wang, Bin ; Yi, Deqing ; Jin, Lei ; Li, Zhiwen ; Liu, Jufen ; Zhang, Yali ; Qiu, Xinghua ; Liu, Wenxin ; Tao, Shu ; Ren, Aiguo
刊名	science of the total environment
	2014
关键词	Neural tube defect Risk Organochlorine pesticides Maternal serum Case-control study PERSISTENT ORGANIC POLLUTANTS HUMAN BLOOD-PLASMA POLYCHLORINATED-BIPHENYLS EXPOSURE URBAN OCPS CONTAMINANTS ASSOCIATION INHABITANTS METABOLITES
DOI	10.1016/j.scitotenv.2014.05.075
英文摘要	Organochlorine pesticides (OCPs) in placental tissue have been reported to be associated with an increased risk for fetal neural tube defects (NTDs). Our case-control study was performed to explore the association between maternal serum OCP concentration and NTD risk in offspring. Serum samples were collected from 117 mothers who delivered NTD infants (case group) and 121 mothers who delivered healthy infants (control group). Only three of the 25 OCPs were detected in more than half of the maternal serum samples. The median concentration of total OCPs in the case group was significantly higher than that of the control group. However, no dose-response relationships between higher levels of any individual OCPs or total OCPs and the risk of NTDs or subtypes were observed in either the unadjusted binary unconditional logistic regression model or the model adjusted by potential confounders. We conclude that no clear association between maternal serum OCP residues and NTD risk in offspring was observed in this population. Capsule: No clear association between maternal serum levels of organochlorine pesticides and risk of neural tube defects in offspring was observed for a Chinese population. (C) 2014 Elsevier B.V. All rights reserved.; Environmental Sciences; SCI(E); PubMed; 2; ARTICLE; renag@bjmu.edu.cn; 1037-1043; 490
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/188977]
专题	城市与环境学院环境科学与工程学院
推荐引用方式 GB/T 7714	Wang, Bin,Yi, Deqing,Jin, Lei,et al. Organochlorine pesticide levels inmaternal serumand risk of neural tube defects in offspring in Shanxi Province, China: A case-control study[J]. science of the total environment,2014.
APA	Wang, Bin.,Yi, Deqing.,Jin, Lei.,Li, Zhiwen.,Liu, Jufen.,...&Ren, Aiguo.(2014).Organochlorine pesticide levels inmaternal serumand risk of neural tube defects in offspring in Shanxi Province, China: A case-control study.science of the total environment.
MLA	Wang, Bin,et al."Organochlorine pesticide levels inmaternal serumand risk of neural tube defects in offspring in Shanxi Province, China: A case-control study".science of the total environment (2014).