Persistent Expression of VCAM1 in Radial Glial Cells Is Required for the   Embryonic Origin of Postnatal Neural Stem Cells

doi:10.1016/j.neuron.2017.06.047

CORC > 北京大学 > 生命科学学院

	Persistent Expression of VCAM1 in Radial Glial Cells Is Required for the Embryonic Origin of Postnatal Neural Stem Cells
	Hu, Xiao-Ling ; Chen, Guo ; Zhang, Sanguo ; Zheng, Jiangli ; Wu, Jun ; Bai, Qing-Ran ; Wang, Yue ; Li, Ji ; Wang, Huanhuan ; Feng, Han ; Li, Jia ; Sun, Xicai ; Xia, Qijun ; Yang, Fan ; Hang, Jing ; Qi, Chang ; Phoenix, Timothy N. ; Temple, Sally ; Shen, Qin
刊名	NEURON
	2017
关键词	ADULT MAMMALIAN BRAIN SUBVENTRICULAR ZONE ADHESION MOLECULE-1 BETA-CATENIN BONE-MARROW MOUSE NEUROGENESIS LINEAGE PROGENITORS NICHE
DOI	10.1016/j.neuron.2017.06.047
英文摘要	During development, neural stem cells (NSCs) undergo transitions from neuroepithelial cells to radial glial cells (RGCs), and later, a subpopulation of slowly dividing RGCs gives rise to the quiescent adult NSCs that populate the ventricular-subventricular zone (V-SVZ). Here we show that VCAM1, a transmembrane protein previously found in quiescent adult NSCs, is expressed by a subpopulation of embryonic RGCs, in a temporal and region-specific manner. Loss of VCAM1 reduced the number of active embryonic RGCs by stimulating their premature neuronal differentiation while preventing quiescence in the slowly dividing RGCs. This in turn diminished the embryonic origin of postnatal NSCs, resulting in loss of adult NSCs and defective V-SVZ regeneration. VCAM1 affects the NSC fate by signaling through its intracellular domain to regulate beta-catenin signaling in a context-dependent manner. Our findings provide new insight on how stem cells in the embryo are preserved to meet the need for growth and regeneration.; Tsinghua Center for Life Sciences (CLS); National Natural Science Foundation of China (NSFC) [31200798, 20131351353]; Tsinghua CLS; SCI(E); ARTICLE; 2; 309-+; 95
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/472079]
专题	生命科学学院
推荐引用方式 GB/T 7714	Hu, Xiao-Ling,Chen, Guo,Zhang, Sanguo,et al. Persistent Expression of VCAM1 in Radial Glial Cells Is Required for the Embryonic Origin of Postnatal Neural Stem Cells[J]. NEURON,2017.
APA	Hu, Xiao-Ling.,Chen, Guo.,Zhang, Sanguo.,Zheng, Jiangli.,Wu, Jun.,...&Shen, Qin.(2017).Persistent Expression of VCAM1 in Radial Glial Cells Is Required for the Embryonic Origin of Postnatal Neural Stem Cells.NEURON.
MLA	Hu, Xiao-Ling,et al."Persistent Expression of VCAM1 in Radial Glial Cells Is Required for the Embryonic Origin of Postnatal Neural Stem Cells".NEURON (2017).