BATMAN-TCM: a Bioinformatics Analysis Tool for Molecular mechANism of   Traditional Chinese Medicine

doi:10.1038/srep21146

CORC > 北京大学 > 化学与分子工程学院

	BATMAN-TCM: a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine
	Liu, Zhongyang ; Guo, Feifei ; Wang, Yong ; Li, Chun ; Zhang, Xinlei ; Li, Honglei ; Diao, Lihong ; Gu, Jiangyong ; Wang, Wei ; Li, Dong ; He, Fuchu
刊名	SCIENTIFIC REPORTS
	2016
关键词	DRUG DISCOVERY SYSTEMS PHARMACOLOGY HEART-FAILURE INTERACTION NETWORKS THERAPEUTIC TARGET HERBAL MEDICINES DATABASE SIMILARITY OVEREXPRESSION INFORMATION
DOI	10.1038/srep21146
英文摘要	Traditional Chinese Medicine (TCM), with a history of thousands of years of clinical practice, is gaining more and more attention and application worldwide. And TCM-based new drug development, especially for the treatment of complex diseases is promising. However, owing to the TCM's diverse ingredients and their complex interaction with human body, it is still quite difficult to uncover its molecular mechanism, which greatly hinders the TCM modernization and internationalization. Here we developed the first online Bioinformatics Analysis Tool for Molecular mechANism of TCM (BATMAN-TCM). Its main functions include 1) TCM ingredients' target prediction; 2) functional analyses of targets including biological pathway, Gene Ontology functional term and disease enrichment analyses; 3) the visualization of ingredient-target-pathway/disease association network and KEGG biological pathway with highlighted targets; 4) comparison analysis of multiple TCMs. Finally, we applied BATMAN-TCM to Qishen Yiqi dripping Pill (QSYQ) and combined with subsequent experimental validation to reveal the functions of renin-angiotensin system responsible for QSYQ's cardioprotective effects for the first time. BATMAN-TCM will contribute to the understanding of the "multi-component, multi-target and multi-pathway" combinational therapeutic mechanism of TCM, and provide valuable clues for subsequent experimental validation, accelerating the elucidation of TCM's molecular mechanism.; Program of International ST Cooperation [2014DFB30020]; National Key Technology RD Program [2012BAI29B07]; Chinese High Technology Research and Development [2012AA020201, 2015AA020108]; National Natural Science Foundation of China [31271407]; SCI(E); PubMed; ARTICLE; wangwei26960@126.com; lidong.bprc@foxmail.com; hefc@nic.bmi.ac.cn; 21146; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/434923]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Liu, Zhongyang,Guo, Feifei,Wang, Yong,et al. BATMAN-TCM: a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine[J]. SCIENTIFIC REPORTS,2016.
APA	Liu, Zhongyang.,Guo, Feifei.,Wang, Yong.,Li, Chun.,Zhang, Xinlei.,...&He, Fuchu.(2016).BATMAN-TCM: a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine.SCIENTIFIC REPORTS.
MLA	Liu, Zhongyang,et al."BATMAN-TCM: a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine".SCIENTIFIC REPORTS (2016).