Fabrication of zwitterionic and pH-responsive polyacetal dendrimers for anticancer drug delivery

doi:10.1039/c9bm00606k

CORC > 化学研究所 > 中国科学院化学研究所

	Fabrication of zwitterionic and pH-responsive polyacetal dendrimers for anticancer drug delivery
	Wang, Yaqiang; Huang, Da; Wang, Xing; Yang, Fei; Shen, Hong; Wu, Decheng
刊名	BIOMATERIALS SCIENCE
	2019-08-01
卷号	7 期号:8 页码:3238-3248
ISSN号	2047-4830
DOI	10.1039/c9bm00606k
英文摘要	Dendrimer micelles are considered to be the most promising synthetic macromolecules for biomedical applications, but their instability in the blood circulation and undesired release at a non-targeted location have become the major concerns for recent research. Herein, zwitterionic sulfobetaine (SB) functionalized polyacetal dendrimers were fabricated through the alternant aza-Michael addition and thiol-ene click reactions. On account of the acid-labile characteristics of acetal segments and charge reversal effects of sulfobetaine moieties, these uniform dendrimers could form biocompatible and biodegradable micelles in aqueous solutions, which present excellent structural stability, good resistivity to protein absorption and high internalization efficiency for a long period. More importantly, effected by the charge shielding of zwitterions on the surface of polyacetal dendrimers, these DOX-loaded nanoparticles exhibited extremely significant pH-responsive drug release behaviors and remarkable anticancer activity. Thus, we believe that this work not only sheds new light on the application of polyacetal dendrimers but also paves a better way for the development of robust on-demand anti-cancer nanosystems with significant potential for clinical translation.
语种	英语
WOS记录号	WOS:000476955100012
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/82705]
专题	中国科学院化学研究所
作者单位	Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yaqiang,Huang, Da,Wang, Xing,et al. Fabrication of zwitterionic and pH-responsive polyacetal dendrimers for anticancer drug delivery[J]. BIOMATERIALS SCIENCE,2019,7(8):3238-3248.
APA	Wang, Yaqiang,Huang, Da,Wang, Xing,Yang, Fei,Shen, Hong,&Wu, Decheng.(2019).Fabrication of zwitterionic and pH-responsive polyacetal dendrimers for anticancer drug delivery.BIOMATERIALS SCIENCE,7(8),3238-3248.
MLA	Wang, Yaqiang,et al."Fabrication of zwitterionic and pH-responsive polyacetal dendrimers for anticancer drug delivery".BIOMATERIALS SCIENCE 7.8(2019):3238-3248.