The relationships between arsenic methylation and both skin lesions and hypertension caused by chronic exposure to arsenic in drinking water

doi:10.1016/j.etap.2017.05.009

	The relationships between arsenic methylation and both skin lesions and hypertension caused by chronic exposure to arsenic in drinking water
	Wei, Binggan 1; Yu, Jiangping 1; Wang, Jing 1,2; Yang, Linsheng 1,2; Li, Hairong 1,2; Kong, Chang 1,2; Xia, Yajuan 3; Wu, Kegong 3
刊名	ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
	2017-07-01
卷号	53 页码:89-94
关键词	Arsenic Methylation Skin lesions Hypertension Drinking water
ISSN号	1382-6689
DOI	10.1016/j.etap.2017.05.009
通讯作者	Yang, Linsheng(yangls@igsnrr.ac.cn) ; Li, Hairong(lihr@igsnrr.ac.cn)
英文摘要	The associations between arsenic exposure, arsenic methylation, and the prevalence of skin lesions and hypertension are investigated. The results indicate that the HS (hypertension and skin lesions) group and the S (skin lesions) group have higher urinary concentrations of iAs (inorganic arsenic), MMA (monomethylarsonic acid), DMA (dimethylarsinous acid) and%MMA, and lower SMI (secondary arsenic methylation index) compared to the H (hypertension) and N (without both hypertension and skin lesions) groups. The arsenic content in water which caused H may be lower than that which caused HS and S. In addition, the odds ratios suggest that higher urinary concentrations of iAs and MMA, %iAs, %MMA and PMI elevate the prevalence of only hypertension and skin lesions, and both hypertension and skin lesions. However, higher%DMA and SMI, and lower%MMA increase the prevalence of both hypertension and skin lesions compared to that of only skin lesions. It can be concluded that skin lesions subjects have higher prevalence of hypertension. Hypertension subjects may have higher prevalence of skin lesions. Lower%DMA and SMI, higher%iAs, %MMA and PMI enhance the prevalence of only hypertension and skin lesions, and both hypertension and skin lesions. Moreover, iAs and MMA may have higher toxicity and lead to both hypertension and skin lesions than to only hypertension.
资助项目	State Key Program of National Natural Science of China[41230749] ; National Natural Science of China[41601559]
WOS关键词	INNER-MONGOLIA ; BLOOD-PRESSURE ; NORTHERN CHINA ; CAPACITY ; METABOLITES ; AREA ; INDIVIDUALS ; ASSOCIATION ; TAIWAN ; COHORT
WOS研究方向	Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000406566200012
资助机构	State Key Program of National Natural Science of China ; National Natural Science of China
内容类型	期刊论文
源URL	[http://ir.igsnrr.ac.cn/handle/311030/61483]
专题	中国科学院地理科学与资源研究所
通讯作者	Yang, Linsheng; Li, Hairong
作者单位	1.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Key Lab Land Surface Pattern & Simulat, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing, Peoples R China 3.Inner Mongolia Ctr Endem Dis Control & Res, Hohhot, Inner Mongolia, Peoples R China
推荐引用方式 GB/T 7714	Wei, Binggan,Yu, Jiangping,Wang, Jing,et al. The relationships between arsenic methylation and both skin lesions and hypertension caused by chronic exposure to arsenic in drinking water[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2017,53:89-94.
APA	Wei, Binggan.,Yu, Jiangping.,Wang, Jing.,Yang, Linsheng.,Li, Hairong.,...&Wu, Kegong.(2017).The relationships between arsenic methylation and both skin lesions and hypertension caused by chronic exposure to arsenic in drinking water.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,53,89-94.
MLA	Wei, Binggan,et al."The relationships between arsenic methylation and both skin lesions and hypertension caused by chronic exposure to arsenic in drinking water".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 53(2017):89-94.