Blood Pressure Associated with Arsenic Methylation and Arsenic Metabolism Caused by Chronic Exposure to Arsenic in Tube Well Water

doi:10.3967/bes2017.044

	Blood Pressure Associated with Arsenic Methylation and Arsenic Metabolism Caused by Chronic Exposure to Arsenic in Tube Well Water
	Wei Bing Gan 1; Ye Bi Xiong 2; Yu Jiang Ping 1; Yang Lin Sheng 1; Li Hai Rong 1; Xia Ya Juan 3; Wu Ke Gong 3
刊名	BIOMEDICAL AND ENVIRONMENTAL SCIENCES
	2017-05-01
卷号	30 期号:5 页码:333-+
关键词	Arsenic Arsenic methylation Arsenic metabolism Blood pressure Drinking water
ISSN号	0895-3988
DOI	10.3967/bes2017.044
通讯作者	Yang Lin Sheng(yangls@igsnrr.ac.cn) ; Li Hai Rong(lihr@igsnrr.ac.cn)
英文摘要	Objective The effects of arsenic exposure from drinking water, arsenic metabolism, and arsenic methylation on blood pressure (BP) were observed in this study. Methods The BP and arsenic species of 560 participants were determined. Logistic regression analysis was applied to estimate the odds ratios of BP associated with arsenic metabolites and arsenic methylation capability. Results BP was positively associated with cumulative arsenic exposure (CAE). Subjects with abnormal diastolic blood pressure (DBP), systolic blood pressure (SBP), and pulse pressure (PP) usually had higher urinary iAs (inorganic arsenic), MMA (monomethylated arsenic), DMA (dimethylated arsenic), and TAs (total arsenic) than subjects with normal DBP, SBP, and PP. The iAs%, MMA%, and DMA% differed slightly between subjects with abnormal BP and those with normal BP. The PMI and SMI were slightly higher in subjects with abnormal PP than in those with normal PP. Conclusion Our findings suggest that higher CAE may elevate BP. Males may have a higher risk of abnormal DBP, whereas females have a higher risk of abnormal SBP and PP. Higher urinary iAs may increase the risk of abnormal BP. Lower PMI may elevate the BP. However, higher SMI may increase the DBP and SBP, and lower SMI may elevate the PP.
资助项目	State Key Program of National Natural Science foundation of China[41230749] ; National Natural Science foundation of China[41601559]
WOS关键词	DRINKING-WATER ; INNER-MONGOLIA ; SOUTHWESTERN TAIWAN ; SKIN-LESIONS ; HYPERENDEMIC AREAS ; NORTHERN CHINA ; ENDEMIC AREA ; RISK ; HYPERTENSION ; BANGLADESH
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
语种	英语
出版者	CHINESE CENTER DISEASE CONTROL & PREVENTION
WOS记录号	WOS:000407001700003
资助机构	State Key Program of National Natural Science foundation of China ; National Natural Science foundation of China
内容类型	期刊论文
源URL	[http://ir.igsnrr.ac.cn/handle/311030/61445]
专题	中国科学院地理科学与资源研究所
通讯作者	Yang Lin Sheng; Li Hai Rong
作者单位	1.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Key Lab Land Surface Pattern & Simulat, Beijing 100101, Peoples R China 2.Chinese Ctr Dis Control & Prevent, Inst Environm Hlth & Related Prod Safety, Beijing 100021, Peoples R China 3.Inner Mongolia Ctr Endem Dis Control & Res, Hohhot 010031, Inner Mongolia, Peoples R China
推荐引用方式 GB/T 7714	Wei Bing Gan,Ye Bi Xiong,Yu Jiang Ping,et al. Blood Pressure Associated with Arsenic Methylation and Arsenic Metabolism Caused by Chronic Exposure to Arsenic in Tube Well Water[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2017,30(5):333-+.
APA	Wei Bing Gan.,Ye Bi Xiong.,Yu Jiang Ping.,Yang Lin Sheng.,Li Hai Rong.,...&Wu Ke Gong.(2017).Blood Pressure Associated with Arsenic Methylation and Arsenic Metabolism Caused by Chronic Exposure to Arsenic in Tube Well Water.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,30(5),333-+.
MLA	Wei Bing Gan,et al."Blood Pressure Associated with Arsenic Methylation and Arsenic Metabolism Caused by Chronic Exposure to Arsenic in Tube Well Water".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 30.5(2017):333-+.