An investigation of the health effects caused by exposure to arsenic from drinking water and coal combustion: arsenic exposure and metabolism

doi:10.1007/s11356-017-0203-z

	An investigation of the health effects caused by exposure to arsenic from drinking water and coal combustion: arsenic exposure and metabolism
	Wei, Binggan 1; Yu, Jiangping 1; Kong, Chang 1,2; Li, Hairong 1,2; Yang, Linsheng 1,2; Guo, Zhiwei 3; Cui, Na 3; Xia, Yajuan 3; Wu, Kegong 3
刊名	ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
	2017-11-01
卷号	24 期号:33 页码:25947-25954
关键词	Arsenic Metabolism Methylation Drinking water Coal combustion
ISSN号	0944-1344
DOI	10.1007/s11356-017-0203-z
通讯作者	Li, Hairong(lihr@igsnrr.ac.cn) ; Yang, Linsheng(yangls@igsnrr.ac.cn)
英文摘要	Few studies have been conducted to compare arsenic exposure, metabolism, and methylation in populations exposed to arsenic in drinking water and from coal combustion. Therefore, arsenic concentrations in the environment and arsenic speciation in the urine of subjects exposed to arsenic as a consequence of coal combustion in a rural area in Shaanxi province (CCA) and in drinking water in a rural area in Inner Mongolia (DWA) were investigated. The mean arsenic concentrations in drinking water, indoor air, and soil in CCA were 4.52 mu g/L, 0.03 mg/m(3), and 14.93 mg/kg, respectively. The mean arsenic concentrations in drinking water and soil in DWA were 144.71 mu g/L and 10.19 mg/kg, respectively, while the level in indoor air was lower than the limit of detection. The total daily intakes of arsenic in DWA and CCA were 4.47 and 3.13 mu g/day.kg, respectively. The mean urinary concentrations of inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsenic acid (DMA), and total arsenic (TAs) for subjects with skin lesions in DWA were 50.41, 47.01, 202.66, and 300.08 mu g/L. The concentrations for subjects without skin lesions were 49.76, 44.20, 195.60, and 289.56 mu g/L, respectively. The %iAs, %MMA, and %DMA in the TAs in the urine of subjects from CCA were 12.24, 14.73, and 73.03%, while the corresponding values from DWA were 17.54, 15.57, and 66.89%, respectively. The subjects in DWA typically had a higher %iAs and %MMA, and a lower %DMA, and primary and secondary methylation index (PMI and SMI) than the subjects in CCA. It was concluded that the arsenic methylation efficiency of subjects in DWA and CCA was significantly influenced by chronic exposure to high levels of arsenic in the environment. The lower PMI and SMI values in DWA revealed lower arsenic methylation capacity due to ingestion of arsenic in drinking water. However, it remained unclear if the differences in arsenic metabolism between the two groups were due to differences in exposure levels or in exposure route.
资助项目	State Key Program of National Natural Science of China[41230749] ; National Natural Science of China[41601559]
WOS关键词	METHYLATION CAPACITY ; SKIN-LESIONS ; INNER-MONGOLIA ; CHINA ; GUIZHOU ; RISK ; AREA ; GROUNDWATER ; BANGLADESH ; EFFICIENCY
WOS研究方向	Environmental Sciences & Ecology
语种	英语
出版者	SPRINGER HEIDELBERG
WOS记录号	WOS:000416332100041
资助机构	State Key Program of National Natural Science of China ; National Natural Science of China
内容类型	期刊论文
源URL	[http://ir.igsnrr.ac.cn/handle/311030/60917]
专题	中国科学院地理科学与资源研究所
通讯作者	Li, Hairong; Yang, Linsheng
作者单位	1.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Key Lab Land Surface Pattern & Simulat, 11 A Datun Rd, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing, Peoples R China 3.Inner Mongolia Ctr Dis Control & Res, Hohhot, Peoples R China
推荐引用方式 GB/T 7714	Wei, Binggan,Yu, Jiangping,Kong, Chang,et al. An investigation of the health effects caused by exposure to arsenic from drinking water and coal combustion: arsenic exposure and metabolism[J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,2017,24(33):25947-25954.
APA	Wei, Binggan.,Yu, Jiangping.,Kong, Chang.,Li, Hairong.,Yang, Linsheng.,...&Wu, Kegong.(2017).An investigation of the health effects caused by exposure to arsenic from drinking water and coal combustion: arsenic exposure and metabolism.ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,24(33),25947-25954.
MLA	Wei, Binggan,et al."An investigation of the health effects caused by exposure to arsenic from drinking water and coal combustion: arsenic exposure and metabolism".ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 24.33(2017):25947-25954.