Protective effects of xanthoceraside on learning and memory impairment induced by A beta(25-35) in mice

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	Protective effects of xanthoceraside on learning and memory impairment induced by A beta(25-35) in mice
	Chi, TY; Wang, LH; Qu, C; Yang, BZ; Ji, XF; Wang, Y; Okuyama, T; Yoshihito, O; Zou, LB; Zou, LB, Shenyang Pharmaceut Univ, Dept Life Sci & Biopharmaceut, Shenyang 110016, Peoples R China
刊名	JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
	2009
卷号	11 期号:12 页码:1019-1027
关键词	Xanthoceraside a Beta(25-35) Alzheimer's Disease Learning And Memory
ISSN号	1028-6020
英文摘要	This study examined the effects of xanthoceraside (1) on learning and memory impairment induced in mice by intracerebroventricular injection of aggregated peptide beta-amyloid 25-35 (A beta(25-35)). Learning and memory functions in mice were examined using step-through, Y-maze and water maze tests. Administration of 1 reduced the number of errors and prolonged latency in the step-through test in mice impaired by A beta(25-35). Likewise, latency to find the terminal platform was decreased and the number of right reflects was increased in the water maze test, and the percentage of alternation behaviors in the Y-maze test was increased. Biochemical studies showed that decreased activities of superoxide dismutase, glutathione peroxidase, and acetylcholinesterase, and increased content of malondialdehyde in mice impaired by A beta(25-35) were significantly ameliorated by administration of 1. The present results suggest that 1 may provide a potential treatment strategy for Alzheimer's disease.
学科主题	Plant Sciences ; Applied ; Medicinal ; Chemistry ; Chemistry ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000273725900006
资助机构	Educational Department of Liaoning Province [20060880]; Shenyang Science and Technology Commission [1071060-9-00]
公开日期	2011-09-23
内容类型	期刊论文
源URL	[http://210.72.129.5/handle/321005/53951]
专题	沈阳应用生态研究所_沈阳应用生态研究所
通讯作者	Zou, LB, Shenyang Pharmaceut Univ, Dept Life Sci & Biopharmaceut, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Chi, TY,Wang, LH,Qu, C,et al. Protective effects of xanthoceraside on learning and memory impairment induced by A beta(25-35) in mice[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2009,11(12):1019-1027.
APA	Chi, TY.,Wang, LH.,Qu, C.,Yang, BZ.,Ji, XF.,...&Zou, LB, Shenyang Pharmaceut Univ, Dept Life Sci & Biopharmaceut, Shenyang 110016, Peoples R China.(2009).Protective effects of xanthoceraside on learning and memory impairment induced by A beta(25-35) in mice.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,11(12),1019-1027.
MLA	Chi, TY,et al."Protective effects of xanthoceraside on learning and memory impairment induced by A beta(25-35) in mice".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 11.12(2009):1019-1027.