An i-type lysozyme (CfLyzl) involved in innate immunity is essential for the survival of Chlamys farreri during Vibrio stimulation

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	An i-type lysozyme (CfLyzl) involved in innate immunity is essential for the survival of Chlamys farreri during Vibrio stimulation
	Wang, M. Q.1,3; Wang, B. J.1; Liu, M.1; Jiang, K. Y.1; Wang, L.1,2,4
刊名	ISJ-INVERTEBRATE SURVIVAL JOURNAL
	2018
卷号	15 页码:285-293
关键词	Chlamys farreri Innate immunity Invertebrate type lysozyme
ISSN号	1824-307X
通讯作者	Wang, L.(wanglei@qdio.ac.cn)
英文摘要	Lysozymes act as key components of the innate immunity in invertebrates and play a pivotal role in early defense against invading microbe infection. In this study, an i-type lysozyme homology was identified and characterized in Zhikong scallop Chlamys farreri (designated as CfLyzl). The full-length cDNA sequence of CfLyzl contained a 702 bp open reading frame (ORF), which encoded a polypeptide of 233 amino acids and contained a typical destabilase function domain. The mRNA transcripts of CfLyzl were detectable in all the investigated tissues, including hemocytes, muscle, mantle, gill, hepatopancreas and gonad with the peak level in hemocytes. Being stimulated by Vibrio splendidus, the mRNA transcripts of CfLyzl significantly increased in hemocytes. The CfLyzl-suppressed scallops turned to be more susceptible to Vibrio. All these results indicated that CfLyzl acted as an efficient effector in the innate immunity and was also essential for hosts' survival during Vibrio stimulation in Zhikong scallop.
资助项目	National Natural Science Foundation of China[U1706209] ; Polit National Laboratory for Marine Science and Technology[2016ASKJ07] ; Science and Technology Service Network Plan (STS) Major Deployment Project[KFZD-SW-106] ; STS Regional Centre Project (Fujian province) from Chinese Academy of Sciences
WOS研究方向	Immunology ; Zoology
语种	英语
出版者	INVERTEBRATE SURVIVAL JOURNAL
WOS记录号	WOS:000443548300004
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/159997]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Wang, L.
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol, Res Platform Marine Mol Biotechnol, Qingdao 266237, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266400, Peoples R China
推荐引用方式 GB/T 7714	Wang, M. Q.,Wang, B. J.,Liu, M.,et al. An i-type lysozyme (CfLyzl) involved in innate immunity is essential for the survival of Chlamys farreri during Vibrio stimulation[J]. ISJ-INVERTEBRATE SURVIVAL JOURNAL,2018,15:285-293.
APA	Wang, M. Q.,Wang, B. J.,Liu, M.,Jiang, K. Y.,&Wang, L..(2018).An i-type lysozyme (CfLyzl) involved in innate immunity is essential for the survival of Chlamys farreri during Vibrio stimulation.ISJ-INVERTEBRATE SURVIVAL JOURNAL,15,285-293.
MLA	Wang, M. Q.,et al."An i-type lysozyme (CfLyzl) involved in innate immunity is essential for the survival of Chlamys farreri during Vibrio stimulation".ISJ-INVERTEBRATE SURVIVAL JOURNAL 15(2018):285-293.