Effects of arsenic methylation and metabolism on the changes of arsenic-related skin lesions

doi:10.1007/s11356-018-2512-2

	Effects of arsenic methylation and metabolism on the changes of arsenic-related skin lesions
	Wei, Binggan 1; Yu, Jiangping 1; Kong, Chang 1,2; Li, Hairong 1,2; Yang, Linsheng 1,2; Xia, Yajuan 3; Wu, Kegong 3
刊名	ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
	2018-08-01
卷号	25 期号:24 页码:24394-24402
关键词	Urinary arsenic Skin lesion change Drinking water Metabolism Methylation
ISSN号	0944-1344
DOI	10.1007/s11356-018-2512-2
通讯作者	Li, Hairong(lihr@igsnrr.ac.cn) ; Yang, Linsheng(yangls@igsnrr.ac.cn)
英文摘要	Little was known about the arsenic metabolism and arsenic methylation associated with the changes of skin lesions after reducing the arsenic in drinking water (WAs). Therefore, urinary concentrations and proportions of arsenic species were determined for recovery (RC), improvement (IC), persistent (PE), aggravation (AC), new incidence (NC), and no sign (HC) groups based on the changes of skin lesions between before (in 2004) and after (in 2017) WAs reduction. The results indicate that the urinary concentrations of inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and total arsenic (TAs) were much higher for RC and IC groups than for the other groups in 2004, while these values varied slightly among the groups in 2017. The urinary %iAs of all the groups was significantly decreased after WAs reduction. In contrast, the urinary %DMA of RC, IC, AC, and NC groups was increased. From 2004 to 2017, the PE and HC groups had lower decrease rate of %iAs and %MMA, and increase rate of %DMA, primary methylation index (PMI), and secondary methylation index (SMI) after WAs reduction. The adjusted odd ratios (ORs) showed that the RC, IC, AC, and NC groups were positively related with %iAs and %MMA and were negatively correlated with %DMA, PMI, and SMI before WAs reduction. It can be concluded that higher urinary %iAs and %MMA before WAs reduction increased the probability of skin lesions recovery and improvement, and the risks of skin lesions aggravation and incidence. Higher increase rate of urinary %DMA was positively associated with of skin lesions recovery and improvement. Moreover, higher urinary %iAs and %MMA or lower increase rate of urinary %DMA might increase the risk of skin lesions aggravation.
资助项目	National Natural Science Foundation of China[41601559] ; State Key Program of National Natural Science of China[41230749]
WOS关键词	DRINKING-WATER ; INNER-MONGOLIA ; NORTHERN CHINA ; CAPACITY ; INDIVIDUALS ; BANGLADESH ; CANCER ; AREA ; RISK ; RESIDENTS
WOS研究方向	Environmental Sciences & Ecology
语种	英语
出版者	SPRINGER HEIDELBERG
WOS记录号	WOS:000441784000082
资助机构	National Natural Science Foundation of China ; State Key Program of National Natural Science of China
内容类型	期刊论文
源URL	[http://ir.igsnrr.ac.cn/handle/311030/54408]
专题	中国科学院地理科学与资源研究所
通讯作者	Li, Hairong; Yang, Linsheng
作者单位	1.Chinese Acad Sci, Key Lab Land Surface Pattern & Simulat, Inst Geog Sci & Nat Resources Res, 11 A Datun Rd, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing, Peoples R China 3.Inner Mongolia Ctr Comprehens Dis Control & Preve, Hohhot, Inner Mongolia, Peoples R China
推荐引用方式 GB/T 7714	Wei, Binggan,Yu, Jiangping,Kong, Chang,et al. Effects of arsenic methylation and metabolism on the changes of arsenic-related skin lesions[J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,2018,25(24):24394-24402.
APA	Wei, Binggan.,Yu, Jiangping.,Kong, Chang.,Li, Hairong.,Yang, Linsheng.,...&Wu, Kegong.(2018).Effects of arsenic methylation and metabolism on the changes of arsenic-related skin lesions.ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,25(24),24394-24402.
MLA	Wei, Binggan,et al."Effects of arsenic methylation and metabolism on the changes of arsenic-related skin lesions".ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 25.24(2018):24394-24402.