Prediction of ligand modulation patterns on membrane receptors via lyysine reactivity profiling

doi:10.1039/c9cc00520j

	Prediction of ligand modulation patterns on membrane receptors via lyysine reactivity profiling
	Zhou, Ye 1,2; Liu, Zheyi 1; Zhang, Jinbao 3; Dou, Tongyi 1; Chen, Jin 1; Ge, Guangbo 1,4; Zhu, Shujia 3; Wang, Fangjun 1
刊名	CHEMICAL COMMUNICATIONS
	2019-04-18
卷号	55 期号:30 页码:4311-4314
ISSN号	1359-7345
DOI	10.1039/c9cc00520j
通讯作者	Zhu, Shujia(shujiazhu@ion.ac.cn) ; Wang, Fangjun(wangfj@dicp.ac.cn)
英文摘要	Herein we provide a mass spectrometry-based lysine reactivity profiling strategy to monitor the ligand modulation of protein receptors, which is achieved by active dimethyl labeling of lysine residues and comparison of the alterations of labeling reactivity during ligand binding. The small-molecule ligand modulation patterns on the catechol-Omethyltransferase and the N-methyl-D-aspartate receptors have been predicted, including both binding regions and related conformational changes.
资助项目	National Key R&D Program of China[2016YFF0200504] ; National Natural Science Foundation of China[91853101] ; National Natural Science Foundation of China[21675152] ; DICP[ZZBS201603] ; Shanghai Rising-Star Program[17QA1404800]
WOS关键词	NMDA RECEPTOR ; ALLOSTERIC MODULATORS ; MOLECULAR-MECHANISMS ; MASS-SPECTROMETRY ; METHYLATION ; IDENTIFICATION ; SUBUNIT ; GLYCINE ; ENZYMES ; BINDING
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000467979900037
资助机构	National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; Shanghai Rising-Star Program ; Shanghai Rising-Star Program ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; Shanghai Rising-Star Program ; Shanghai Rising-Star Program ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; Shanghai Rising-Star Program ; Shanghai Rising-Star Program ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; Shanghai Rising-Star Program ; Shanghai Rising-Star Program
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/171907]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Zhu, Shujia; Wang, Fangjun
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Ye,Liu, Zheyi,Zhang, Jinbao,et al. Prediction of ligand modulation patterns on membrane receptors via lyysine reactivity profiling[J]. CHEMICAL COMMUNICATIONS,2019,55(30):4311-4314.
APA	Zhou, Ye.,Liu, Zheyi.,Zhang, Jinbao.,Dou, Tongyi.,Chen, Jin.,...&Wang, Fangjun.(2019).Prediction of ligand modulation patterns on membrane receptors via lyysine reactivity profiling.CHEMICAL COMMUNICATIONS,55(30),4311-4314.
MLA	Zhou, Ye,et al."Prediction of ligand modulation patterns on membrane receptors via lyysine reactivity profiling".CHEMICAL COMMUNICATIONS 55.30(2019):4311-4314.