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	Tracing the epidemic history of hiv-1 crf01_ ae clusters using near-complete genome sequences
	Li, Xingguang1,2; Liu, Haizhou3; Liu, Lu4,5; Feng, Yi1,2; Kalish, Marcia L.6; Ho, Simon Y. W.7; Shao, Yiming1,2
刊名	Scientific reports
	2017-06-22
卷号	7页码:11
ISSN号	2045-2322
DOI	10.1038/s41598-017-03820-8
通讯作者	Shao, yiming(yshao08@gmail.com)
英文摘要	Human immunodeficiency virus (hiv) has a number of circulating recombinant forms that are the product of recombination between different hiv subtypes. the first circulating recombinant form of hiv-1 to be identified was crf01_ae, which originated in central africa and is now most prevalent in southeast and east asia. in this study, we investigated the timescale, evolutionary history, and population genetics of the hiv-1 crf01_ae strains primarily responsible for the epidemic in asia. a further aim of our study was to define and standardize the nomenclature and provide well-characterized reference sequences for the phylogenetic transmission clusters of crf01_ae. we analysed a data set of 334 near-complete genome sequences from various risk groups, sampled between 1990 and 2011 from nine countries. phylogenetic analyses of these sequences were performed using maximum likelihood and bayesian methods. our study confirms that the diversity of hiv-1 crf01_ae originated in central africa in the mid-1970s, was introduced into thailand between 1979 and 1982, and began expanding there shortly afterwards (1982-1984). subsequently, multiple clusters significantly contributed to china's hiv epidemic. a bayesian skyline plot revealed the rapid expansion of crf01_ae in china around 1999-2000. we identified at least eight different clusters of hiv-1 crf01_ae formed by rapid expansion into different risk groups and geographic regions in china since the late 1980s.
WOS关键词	HUMAN-IMMUNODEFICIENCY-VIRUS ; ENVELOPE GLYCOPROTEIN ; PHYLOGENETIC ANALYSIS ; MOLECULAR SEQUENCES ; NORTHERN THAILAND ; AFRICAN ORIGIN ; RISK-FACTORS ; RECOMBINANT ; CHINA ; MEN
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000403874900007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373413
专题	武汉病毒研究所
通讯作者	Shao, Yiming
作者单位	1.Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China 2.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China 3.Univ Chinese Acad Sci, Ctr Emerging Infect Dis, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China 4.Shantou Univ, Med Coll, Shantou 515041, Peoples R China 5.South China Agr Univ, Coll Vet Med, Guangzhou 510642, Guangdong, Peoples R China 6.Vanderbilt Univ, Sch Med, Vanderbilt Inst Global Hlth, Nashville, TN 37212 USA 7.Univ Sydney, Sch Life & Environm Sci, Sydney, NSW 2006, Australia
推荐引用方式 GB/T 7714	Li, Xingguang,Liu, Haizhou,Liu, Lu,et al. Tracing the epidemic history of hiv-1 crf01_ ae clusters using near-complete genome sequences[J]. Scientific reports,2017,7:11.
APA	Li, Xingguang.,Liu, Haizhou.,Liu, Lu.,Feng, Yi.,Kalish, Marcia L..,...&Shao, Yiming.(2017).Tracing the epidemic history of hiv-1 crf01_ ae clusters using near-complete genome sequences.Scientific reports,7,11.
MLA	Li, Xingguang,et al."Tracing the epidemic history of hiv-1 crf01_ ae clusters using near-complete genome sequences".Scientific reports 7(2017):11.

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