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	March3 attenuates il-1 beta-triggered inflammation by mediating k48-linked polyubiquitination and degradation of il-1ri
	Lin, Heng1,2; Gao, Deng1; Hu, Ming-Ming1; Zhang, Man2; Wu, Xiao-Xia2; Feng, Lu1; Xu, Wen-Hua1; Yang, Qing1; Zhong, Xuan2; Wei, Jin1
刊名	Proceedings of the national academy of sciences of the united states of america
	2018-12-04
卷号	115期号:49页码:12483-12488
关键词	March3 Il-1 Listeria monocytogenes Polyubiquitination Inflammation
ISSN号	0027-8424
DOI	10.1073/pnas.1806217115
通讯作者	Shu, hong-bing(shuh@whu.edu.cn)
英文摘要	The proinflammatory cytokine il-1 beta plays critical roles in inflammatory and autoimmune diseases. il-1 beta signaling is tightly regulated to avoid excessive inflammatory response. in this study, we identified the e3 ubiquitin ligase membrane-associated ring-ch-type finger 3 (march3) as a critical negative regulator of il-1 beta-triggered signaling. overexpression of march3 inhibited il-1 beta-triggered activation of nf-kappa b as well as expression of inflammatory genes, whereas march3 deficiency had the opposite effects. march3-deficient mice produced higher levels of serum inflammatory cytokines and were more sensitive to inflammatory death upon il-1 beta injection or listeria monocytogenes infection. mechanistically, march3 was associated with il-1 receptor i (il-1ri) and mediated its k48-linked polyubiquitination at k409 and lysosomal-dependent degradation. furthermore, il-1 beta stimulation triggered dephosphorylation of march3 by cdc25a and activation of its e3 ligase activity. our findings suggest that march3-mediated il-1ri degradation is an important mechanism for attenuating il-1 beta-triggered inflammatory response.
WOS关键词	NF-KAPPA-B ; DOWN-REGULATION ; RECEPTOR ; ACTIVATION ; FAMILY ; IRAK ; ADAPTER ; UBIQUITINATION ; TRAFFICKING ; STABILITY
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATL ACAD SCIENCES
WOS记录号	WOS:000452124700051
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373212
专题	武汉病毒研究所
通讯作者	Shu, Hong-Bing
作者单位	1.Wuhan Univ, Dept Infect Dis, Med Res Inst, Zhongnan Hosp,Sch Med, Wuhan, Hubei, Peoples R China 2.Wuhan Univ, Coll Life Sci, Wuhan 430072, Hubei, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Lin, Heng,Gao, Deng,Hu, Ming-Ming,et al. March3 attenuates il-1 beta-triggered inflammation by mediating k48-linked polyubiquitination and degradation of il-1ri[J]. Proceedings of the national academy of sciences of the united states of america,2018,115(49):12483-12488.
APA	Lin, Heng.,Gao, Deng.,Hu, Ming-Ming.,Zhang, Man.,Wu, Xiao-Xia.,...&Shu, Hong-Bing.(2018).March3 attenuates il-1 beta-triggered inflammation by mediating k48-linked polyubiquitination and degradation of il-1ri.Proceedings of the national academy of sciences of the united states of america,115(49),12483-12488.
MLA	Lin, Heng,et al."March3 attenuates il-1 beta-triggered inflammation by mediating k48-linked polyubiquitination and degradation of il-1ri".Proceedings of the national academy of sciences of the united states of america 115.49(2018):12483-12488.

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