The versatile functions of LRR-only proteins in mollusk Chlamys farreri

doi:10.1016/j.dci.2017.08.005

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	The versatile functions of LRR-only proteins in mollusk Chlamys farreri
	Wang, Mengqiang1 ; Wang, Lingling 2,3; Jia, Zhihao 1,4; Wang, Xiudan1,4 ; Yi, Qilin 3; Zhao, Lv 1,4; Song, Linsheng 2,3
刊名	DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
	2017-12-01
卷号	77 页码:188-199
关键词	Immunomodulation Innate Immunity Pattern Recognition Scallop
DOI	10.1016/j.dci.2017.08.005
文献子类	Article
英文摘要	Leucine-rich repeat (LRR)-only proteins are involved in the innate immune responses as they mediate protein-ligand interactions. In the present study, three novel LRR-only proteins, CfLRRop-4, CfLRRop-5 and CfLRRop-6, were identified and characterized from Zhikong scallop Chlamys farreri. They all contained LRR motifs with consensus signature sequences of LxxLxLxxNxL or LxxLxLxxCxxL. All the mRNA transcripts of three CfLRRops were high abundant in hepatopancreas, gills and gonads, and their mRNA transcripts in hemocytes could respond to the stimulations of different microbes, including Vibrio anguillarum, Micrococcus luteus and Pichia pastoris. These three CfLRRops exhibited similar ligand binding and recognition characteristics as Toll-like receptors (TLRs) and NOD-like receptors (NLRs). The immune effectors, including tumor necrosis factor alpha, superoxide dismutase, catalase and lysozyme, varied significantly after the scallops were stimulated by recombinant LRR-only proteins. All these results indicated that LRR-only proteins are functionally differentiated and exhibit different immunomodulation activities on various downstream immune effectors. (C) 2017 Elsevier Ltd. All rights reserved.
语种	英语
WOS记录号	WOS:000413387100021
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.qdio.ac.cn/handle/337002/143238]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Funct Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China 3.Dalian Ocean Univ, Liaoning Key Lab Marine Anim Immunol & Dis Contro, 52 Heishijiao St, Dalian 116023, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Mengqiang,Wang, Lingling,Jia, Zhihao,et al. The versatile functions of LRR-only proteins in mollusk Chlamys farreri[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2017,77:188-199.
APA	Wang, Mengqiang.,Wang, Lingling.,Jia, Zhihao.,Wang, Xiudan.,Yi, Qilin.,...&Song, Linsheng.(2017).The versatile functions of LRR-only proteins in mollusk Chlamys farreri.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,77,188-199.
MLA	Wang, Mengqiang,et al."The versatile functions of LRR-only proteins in mollusk Chlamys farreri".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 77(2017):188-199.