Mulberry Diels-Alder-type adducts from Morus alba as multi-targeted agents for Alzheimer's disease | |
Xia, Chun-Li; Tang, Gui-Hua; Guo, Yan-Qiong; Xu, You-Kai; Huang, Zhi-Shu; Yin, Sheng4 | |
刊名 | PHYTOCHEMISTRY |
2019 | |
卷号 | 157期号:x页码:82-91 |
关键词 | Neurodegenerative Diseases Directed Ligands Tree Constituents Design Derivatives Flavonoids Decade Target Beta |
ISSN号 | 0031-9422 |
DOI | 10.1016/j.phytochem.2018.10.028 |
英文摘要 | Mulberry Diels-Alder-type adducts (MDAAs) are a group of structurally unique natural products biosynthetically derived from the intermolecular [4 + 2] cycloaddition of a dehydroprenylphenol and a chalcone. In the current study, ten MDAAs, including an undescribed one, inethermulberrofuran C, were isolated from the root bark of Morus alba. The anti-Alzheimer's disease (anti-AD) properties of these isolates were systematically screened for a series of potential targets (A beta self-aggregation, tau aggregation, and ChEs) as well as the anti-neuroinflammatory and neuroprotective activities. Four compounds, mulberrofuran C, mulberrofuran K, mulberrofuran G, and isomulberrofuran G, turned out to be potent multi-targeted agents for AD. Among them, mulberrofuran K with a good blood-brain barrier (BBB) permeability (8.7 +/- 0.3 x 10(-6) cm/s) was selected as a promising candidate for further mechanism study in glutamate-induced HT22 cell model, which showed its neuroprotective ability on up-regulation of the glutathione (GSH) level and suppression of the reactive oxygen species (ROS) production. |
学科主题 | Biochemistry & Molecular Biology ; Plant Sciences |
语种 | 英语 |
WOS记录号 | WOS:000455068200009 |
内容类型 | 期刊论文 |
源URL | [http://ir.xtbg.org.cn/handle/353005/11234] |
专题 | 西双版纳热带植物园_2012年后新成立研究组 西双版纳热带植物园_民族植物学研究组 |
作者单位 | 1.[Xia, Chun-Li 2.Tang, Gui-Hua 3.Guo, Yan-Qiong 4.Huang, Zhi-Shu 5.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China 6.Chinese Acad Sci, Key Lab Trop Plant Resources & Sustainable Use, Xishuangbanna Trop Bot Garden, Menglun 666303, Yunnan, Peoples R China |
推荐引用方式 GB/T 7714 | Xia, Chun-Li,Tang, Gui-Hua,Guo, Yan-Qiong,et al. Mulberry Diels-Alder-type adducts from Morus alba as multi-targeted agents for Alzheimer's disease[J]. PHYTOCHEMISTRY,2019,157(x):82-91. |
APA | Xia, Chun-Li,Tang, Gui-Hua,Guo, Yan-Qiong,Xu, You-Kai,Huang, Zhi-Shu,&Yin, Sheng.(2019).Mulberry Diels-Alder-type adducts from Morus alba as multi-targeted agents for Alzheimer's disease.PHYTOCHEMISTRY,157(x),82-91. |
MLA | Xia, Chun-Li,et al."Mulberry Diels-Alder-type adducts from Morus alba as multi-targeted agents for Alzheimer's disease".PHYTOCHEMISTRY 157.x(2019):82-91. |
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