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	Poly(lactide-co-glycolide)-monomethoxy-poly-(polyethylene glycol) nanoparticles loaded with melatonin protect adipose-derived stem cells transplanted in infarcted heart tissue
	Ma, Qiang1; Yang, Junjie1; Huang, Xu1; Guo, Weisheng2; Li, Sulei1; Zhou, Hao1; Li, Jingwei1; Cao, Feng1; Chen, Yundai1
刊名	Stem cells
	2018-04-01
卷号	36期号:4页码:540-550
关键词	Stem cell transplantation Melatonin Nanoparticles Poly(lactide-co-glycolide)-monomethoxy-poly-(polyethylene glycol) Myocardial infarction
ISSN号	1066-5099
DOI	10.1002/stem.2777
通讯作者	Cao, feng(wind8828@gmail.com) ; Chen, yundai(cyundai@vip.163.com)
英文摘要	Stem cell transplantation is a promising therapeutic strategy for myocardial infarction. however, transplanted cells face low survival rates due to oxidative stress and the inflammatory microenvironment in ischemic heart tissue. melatonin has been used as a powerful endogenous antioxidant to protect cells from oxidative injury. however, melatonin cannot play a long-lasting effect against the hostile microenvironment. nano drug delivery carriers have the ability to protect the loaded drug from degradation in physiological environments in a controlled manner, which results in longer effects and decreased side effects. therefore, we constructed poly(lactide-co-glycolide)-monomethoxy-poly-(polyethylene glycol) (plga-mpeg) nanoparticles to encapsulate melatonin. we tested whether the protective effect of melatonin encapsulated by plga-mpeg nanoparticles (melatonin nanoparticles [mel-nps]) on adipose-derived mesenchymal stem cells (adscs) was enhanced compared to that of free melatonin both in vitro and in vivo. in the in vitro study, we found that mel-nps reduced formation of the p53- cyclophilin d complex, prevented mitochondrial permeability transition pores from opening, and rescued adscs from hypoxia/reoxygenation injury. moreover, mel-nps can achieve higher adsc survival rates than free melatonin in rat myocardial infarction areas, and the therapeutic effects of adscs pretreated with mel-nps were more apparent. hence, the combination of mel-nps and stem cell transplantation may be a promising strategy for myocardial infarction therapy.
WOS关键词	MITOCHONDRIAL PERMEABILITY TRANSITION ; MESENCHYMAL STROMAL CELLS ; PLGA-MPEG NANOPARTICLES ; IN-VIVO ; MYOCARDIAL-INFARCTION ; HYDROGEN-PEROXIDE ; REPAIR ; VITRO ; APOPTOSIS ; SURVIVAL
WOS研究方向	Cell Biology ; Biotechnology & Applied Microbiology ; Oncology ; Hematology
WOS类目	Cell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Oncology ; Cell Biology ; Hematology
语种	英语
出版者	WILEY
WOS记录号	WOS:000428702800007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2178160
专题	高能物理研究所
通讯作者	Cao, Feng; Chen, Yundai
作者单位	1.Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China 2.Natl Ctr Nanosci & Technol, Lab Controllable Nanopharmaceut, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Ma, Qiang,Yang, Junjie,Huang, Xu,et al. Poly(lactide-co-glycolide)-monomethoxy-poly-(polyethylene glycol) nanoparticles loaded with melatonin protect adipose-derived stem cells transplanted in infarcted heart tissue[J]. Stem cells,2018,36(4):540-550.
APA	Ma, Qiang.,Yang, Junjie.,Huang, Xu.,Guo, Weisheng.,Li, Sulei.,...&Chen, Yundai.(2018).Poly(lactide-co-glycolide)-monomethoxy-poly-(polyethylene glycol) nanoparticles loaded with melatonin protect adipose-derived stem cells transplanted in infarcted heart tissue.Stem cells,36(4),540-550.
MLA	Ma, Qiang,et al."Poly(lactide-co-glycolide)-monomethoxy-poly-(polyethylene glycol) nanoparticles loaded with melatonin protect adipose-derived stem cells transplanted in infarcted heart tissue".Stem cells 36.4(2018):540-550.

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