Systematic Engineering for Improved Carbon Economy in the Biosynthesis of Polyhydroxyalkanoates and Isoprenoids

doi:10.3390/ma11081271

	Systematic Engineering for Improved Carbon Economy in the Biosynthesis of Polyhydroxyalkanoates and Isoprenoids
	Zou, Huibin 1,2; Zhang, Tongtong 1; Li, Lei 1; Huang, Jingling 1; Zhang, Nan 1; Shi, Mengxun 1; Hao, He 1; Xian, Mo 2
刊名	MATERIALS
	2018-08-01
卷号	11 期号:8 页码:14
关键词	biosynthesis carbon economy polyhydroxyalkanoates isoprenoids
ISSN号	1996-1944
DOI	10.3390/ma11081271
英文摘要	With the rapid development of synthetic biology and metabolic engineering, a broad range of biochemicals can be biosynthesized, which include polyhydroxyalkanoates and isoprenoids. However, some of the bio-approaches in chemical synthesis have just started to be applied outside of laboratory settings, and many require considerable efforts to achieve economies of scale. One of the often-seen barriers is the low yield and productivity, which leads to higher unit cost and unit capital investment for the bioconversion process. In general, higher carbon economy (less carbon wastes during conversion process from biomass to objective bio-based chemicals) will result in higher bioconversion yield, which results in less waste being generated during the process. To achieve this goal, diversified strategies have been applied; matured strategies include pathway engineering to block competitive pathways, enzyme engineering to enhance the activities of enzymes, and process optimization to improve biomass/carbon yield. In this review, we analyze the impact of carbon sources from different types of biomass on the yield of bio-based chemicals (especially for polyhydroxyalkanoates and isoprenoids). Moreover, we summarize the traditional strategies for improving carbon economy during the bioconversion process and introduce the updated techniques in building up non-natural carbon pathways, which demonstrate higher carbon economies than their natural counterparts.
资助项目	Shandong Province Natural Science Foundation[ZR2015BM011] ; Technology Development Project of Shandong Province[2016GSF121013] ; National Natural Science Foundation[21376156]
WOS关键词	RECOMBINANT ESCHERICHIA-COLI ; POLY-BETA-HYDROXYBUTYRATE ; FED-BATCH CULTIVATION ; SACCHAROMYCES-CEREVISIAE ; POLY(3-HYDROXYBUTYRATE) PRODUCTION ; ALCALIGENES-EUTROPHUS ; MICROBIAL-PRODUCTION ; RALSTONIA-EUTROPHA ; BIODEGRADABLE POLYHYDROXYALKANOATES ; PELOBACTER-CARBINOLICUS
WOS研究方向	Materials Science
语种	英语
出版者	MDPI
WOS记录号	WOS:000444112800008
资助机构	Shandong Province Natural Science Foundation ; Technology Development Project of Shandong Province ; National Natural Science Foundation
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/11831]
专题	中国科学院青岛生物能源与过程研究所
通讯作者	Zou, Huibin
作者单位	1.Qingdao Univ Sci & Technol, Coll Chem Engn, Qingdao 266042, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266101, Peoples R China
推荐引用方式 GB/T 7714	Zou, Huibin,Zhang, Tongtong,Li, Lei,et al. Systematic Engineering for Improved Carbon Economy in the Biosynthesis of Polyhydroxyalkanoates and Isoprenoids[J]. MATERIALS,2018,11(8):14.
APA	Zou, Huibin.,Zhang, Tongtong.,Li, Lei.,Huang, Jingling.,Zhang, Nan.,...&Xian, Mo.(2018).Systematic Engineering for Improved Carbon Economy in the Biosynthesis of Polyhydroxyalkanoates and Isoprenoids.MATERIALS,11(8),14.
MLA	Zou, Huibin,et al."Systematic Engineering for Improved Carbon Economy in the Biosynthesis of Polyhydroxyalkanoates and Isoprenoids".MATERIALS 11.8(2018):14.