Natural and engineered polyhydroxyalkanoate (PHA) synthase: key enzyme in biopolyester production

doi:10.1007/s00253-017-8485-0

CORC > 青岛生物能源与过程研究所 > 中国科学院青岛生物能源与过程研究所 > 材料生物技术研究中心

	Natural and engineered polyhydroxyalkanoate (PHA) synthase: key enzyme in biopolyester production
	Zou, Huibin 1,2; Shi, Mengxun 1; Zhang, Tongtong 1; Li, Lei 1; Li, Liangzhi 3; Xian, Mo 2
刊名	APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
	2017-10-01
卷号	101 期号:20 页码:7417-7426
关键词	Polyhydroxyalkanoate Phasynthase Enzyme Engineering Biopolyester
DOI	10.1007/s00253-017-8485-0
文献子类	Review
英文摘要	With the finite supply of petroleum and increasing concern with environmental issues associated with their harvest and processing, the development of more eco-friendly, sustainable alternative biopolymers that can effectively fill the role of petro-polymers has become a major focus. Polyhydroxyalkanoate (PHA) can be naturally produced by many species of bacteria and the PHA synthase is believed to be key enzyme in this natural pathway. Natural PHA synthases are diverse and can affect the properties of the produced PHAs, such as monomer composition, molecular weights, and material properties. Moreover, recent studies have led to major advances in the searching of PHA synthases that display specific properties, as well as engineering efforts that offer more efficient PHA synthases, increased PHA compound production, or even novel biopolyesters which cannot be naturally produced. In this article, we review the updated information of natural PHA synthases and their engineering strategies for improved performance in polyester production. We also speculate future trends on the development of robust PHA synthases and their application in biopolyester production.
WOS关键词	RECOMBINANT ESCHERICHIA-COLI ; IN-VITRO EVOLUTION ; PSEUDOMONAS SP 61-3 ; RALSTONIA-EUTROPHA ; SUBSTRATE-SPECIFICITY ; MOLECULAR CHARACTERIZATION ; CHEMOENZYMATIC SYNTHESIS ; SATURATION MUTAGENESIS ; BENEFICIAL MUTATION ; COA TRANSFERASE
WOS研究方向	Biotechnology & Applied Microbiology
语种	英语
WOS记录号	WOS:000412122100001
资助机构	Shandong Province Natural Science Foundation(ZR2015BM011) ; Technology Development Project of Shandong Province(2016GSF121013) ; National Natural Science Foundation(21376156)
内容类型	期刊论文
源URL	[http://ir.qibebt.ac.cn/handle/337004/9599]
专题	青岛生物能源与过程研究所_材料生物技术研究中心
作者单位	1.Qingdao Univ Sci & Technol, Coll Chem Engn, Qingdao 266042, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao, Peoples R China 3.Suzhou Univ Sci & Technol, Sch Chem Biol & Mat Engn, Suzhou 215009, Peoples R China
推荐引用方式 GB/T 7714	Zou, Huibin,Shi, Mengxun,Zhang, Tongtong,et al. Natural and engineered polyhydroxyalkanoate (PHA) synthase: key enzyme in biopolyester production[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2017,101(20):7417-7426.
APA	Zou, Huibin,Shi, Mengxun,Zhang, Tongtong,Li, Lei,Li, Liangzhi,&Xian, Mo.(2017).Natural and engineered polyhydroxyalkanoate (PHA) synthase: key enzyme in biopolyester production.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,101(20),7417-7426.
MLA	Zou, Huibin,et al."Natural and engineered polyhydroxyalkanoate (PHA) synthase: key enzyme in biopolyester production".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 101.20(2017):7417-7426.