Fluoxetine administration during adolescence attenuates cognitive and synaptic deficits in adult 3 x TgAD mice

doi:10.1016/j.neuropharm.2017.08.037

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振基础研究部

	Fluoxetine administration during adolescence attenuates cognitive and synaptic deficits in adult 3 x TgAD mice
	Ke, Dan 2,5; Sun, Dong-Sheng 2,5; Gao, Li-Feng 8; Jin, Li 6,7; Wu, Hao 8; Wang, Qun 2,5; Liu, Gong-Ping 2,4,5; Wang, Jian-Zhi 2,4,5; Zhou, You 1; Fan, Shuhao 1
刊名	NEUROPHARMACOLOGY
	2017-11-01
卷号	126 页码:200-212
关键词	Fluoxetine Alzheimer's Disease Cognitive Mri Bdnf
DOI	10.1016/j.neuropharm.2017.08.037
文献子类	Article
英文摘要	Fluoxetine (FLX) has broad neurobiological functions and neuroprotective effects; however, the preventive effects of FLX on cognitive impairments in Alzheimer's disease (AD) have not been reported. Here, we studied whether adolescent administration of fluoxetine can prevent memory deficits in AD transgenic mice that harbour PS1(m146v), APP(swe) and TauP(301L) mutations (3 x TgAD). FLX was applied through peritoneal injection to the mice at postnatal day 35 (p35) for 15 consecutive days, and the effects of FLX were observed at 6-month. We found that adolescent administration of FLX improved learning and memory abilities in 6-month-old 3 x TgAD mice. FLX exposure also increased the sizes of the hippocampal CA1, dentate gyrus (DG) and extensive cortex regions, with increased numbers of neurons and higher dendritic spine density. Meanwhile, the synaptic plasticity of neurons in the hippocampus was remodelled, and the expression levels of synaptic-related proteins were increased along with activation of the cyclic AMP response element-binding (CREB) protein/brain-derived neurotrophic factor (BDNF) signalling pathway. Finally, we found that FLX effectively prevented the increase of beta-amyloid (A beta) levels. These data suggest that adolescent administration of the antidepressant drug FLX can efficiently preserve cognitive functions and improve pathologies in 3 x Tg AD mice. (C) 2017 Elsevier Ltd. All rights reserved.
WOS关键词	CHRONIC ANTIDEPRESSANT TREATMENT ; SPORADIC ALZHEIMERS-DISEASE ; LONG-TERM POTENTIATION ; MOUSE MODEL ; DENDRITIC SPINES ; RAT HIPPOCAMPUS ; CLINICAL-TRIAL ; DOUBLE-BLIND ; A-BETA ; DEPRESSION
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000413879900019
资助机构	National Natural Science Foundation of China(81471303 ; National Natural Science Foundation of China(81471303 ; Ministry of Science and Technology of China(2016YFC1305800 ; Ministry of Science and Technology of China(2016YFC1305800 ; 81303252 ; 81303252 ; 2016YFC1305801) ; 2016YFC1305801) ; 81601204 ; 81601204 ; 81572495) ; 81572495) ; National Natural Science Foundation of China(81471303 ; National Natural Science Foundation of China(81471303 ; Ministry of Science and Technology of China(2016YFC1305800 ; Ministry of Science and Technology of China(2016YFC1305800 ; 81303252 ; 81303252 ; 2016YFC1305801) ; 2016YFC1305801) ; 81601204 ; 81601204 ; 81572495) ; 81572495)
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/11549]
专题	武汉物理与数学研究所_磁共振基础研究部
作者单位	1.Wuhan Univ Sci & Technol, Tianyou Hosp, Dept Neurosurg, Wuhan, Hubei, Peoples R China 2.Huazhong Univ Sci & Technol, Collaborat Innovat Ctr Brain Sci, Key Lab, Minist Educ China Neurol Disorders,Tongji Med Col, Wuhan 430030, Hubei, Peoples R China 3.Hubei Univ Chinese Med, Dept Pathol, Wuhan 430030, Hubei, Peoples R China 4.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong Js 226001, Peoples R China 5.Huazhong Univ Sci & Technol, Dept Pathophysiol, Sch Basic Med, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China 6.Henan Med Coll, Dept Pathophysiol, Zhengzhou 451191, Henan, Peoples R China 7.Henan Med Coll, Henan Key Lab Degenerat Brain Dis, Zhengzhou 451191, Henan, Peoples R China 8.Chinese Acad Sci, Natl Ctr Magnet Resonance Wuhan, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Ke, Dan,Sun, Dong-Sheng,Gao, Li-Feng,et al. Fluoxetine administration during adolescence attenuates cognitive and synaptic deficits in adult 3 x TgAD mice[J]. NEUROPHARMACOLOGY,2017,126:200-212.
APA	Ke, Dan.,Sun, Dong-Sheng.,Gao, Li-Feng.,Jin, Li.,Wu, Hao.,...&Lei, Hao.(2017).Fluoxetine administration during adolescence attenuates cognitive and synaptic deficits in adult 3 x TgAD mice.NEUROPHARMACOLOGY,126,200-212.
MLA	Ke, Dan,et al."Fluoxetine administration during adolescence attenuates cognitive and synaptic deficits in adult 3 x TgAD mice".NEUROPHARMACOLOGY 126(2017):200-212.