Bioactive polyketides and 8,14-seco-ergosterol from fruiting bodies of the ascomycete Daldinia childiae

doi:10.1016/j.phytochem.2017.06.020

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Bioactive polyketides and 8,14-seco-ergosterol from fruiting bodies of the ascomycete Daldinia childiae
	Zhao, Zhen-Zhu 1,3; Chen, He-Ping 1,2; Huang, Ying 1,3; Zhang, Shuai-Bing 1,3; Li, Zheng-Hui 2; Feng, Tao 2; Liu, Ji-Kai 2
刊名	PHYTOCHEMISTRY
	2017-10-01
卷号	142 页码:68-75
关键词	Ascomycete Daldinia Childiae Polyketide Anti-bacterial 8 Anti-no Activity 14-seco-ergosterol
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2017.06.020
英文摘要	Seven previously undescribed polyketides, namely childinins A-G, and one previously undescribed 8,14- (seco-ergosterol, namely childinasterone A, were obtained from the fruiting bodies of Daldinia childiae. Their structures and absolute configurations were established via extensive spectroscopic analyses, single-crystal X-ray diffraction, and TDDFT/ECD calculations. Childinins A represents the first example of natural product possessing a previously undescribed 6H-naphtho[2,1-c]chromen-6-one scaffold. The single crystal X-ray diffraction of childinasterone A unambiguously determined the absolute configuration of a 8,14-seco-ergosterol skeleton. Childinins A, B, F and G (MIC90 54.9 mu g.mL(-1)) showed antibacterial activities. Childinasterone A showed significant anti-NO activity (IC50 21.2 mu M) and weak activities against SMMC-7721, MCF-7 and SW480 cell lines. (C) 2017 Elsevier Ltd. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
WOS记录号	WOS:000408784800008
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/54876]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Zhen-Zhu,Chen, He-Ping,Huang, Ying,et al. Bioactive polyketides and 8,14-seco-ergosterol from fruiting bodies of the ascomycete Daldinia childiae[J]. PHYTOCHEMISTRY,2017,142:68-75.
APA	Zhao, Zhen-Zhu.,Chen, He-Ping.,Huang, Ying.,Zhang, Shuai-Bing.,Li, Zheng-Hui.,...&Liu, Ji-Kai.(2017).Bioactive polyketides and 8,14-seco-ergosterol from fruiting bodies of the ascomycete Daldinia childiae.PHYTOCHEMISTRY,142,68-75.
MLA	Zhao, Zhen-Zhu,et al."Bioactive polyketides and 8,14-seco-ergosterol from fruiting bodies of the ascomycete Daldinia childiae".PHYTOCHEMISTRY 142(2017):68-75.