K-opioid receptor is involved in the cardioprotection induced by exercise training

doi:10.1371/journal.pone.0170463

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	K-opioid receptor is involved in the cardioprotection induced by exercise training
	Geng, X; Zhao, HL; Zhang, SM; Li, J; Tian, F; Feng, N; Fan, R; Jia, M; Guo, HT; Cheng, L
刊名	PLOS ONE
	2017-03-16
卷号	12 期号:3
ISSN号	1932-6203
DOI	10.1371/journal.pone.0170463
文献子类	Article
英文摘要	The present study was designed to test the hypothesis that exercise training elicited a cardioprotective effect against ischemia and reperfusion (I/R) via the K-opioid receptor (K-OR) mediated signaling pathway. Rats were randomly divided into four groups: the control group, the moderate intensity exercise (ME) group, the high intensity exercise (HE) group, and the acute exercise (AE) group. For the exercise training protocols, the rats were subjected to one week of adaptive treadmill training, while from the second week, the ME and HE groups were subjected to eight weeks of exercise training, and the AE group was subjected to three days of adaptive treadmill training and one day of vigorous exercise. After these protocols, the three exercise training groups were divided into different treatment groups, and the rats were subjected to 30 min of ischemia and 120 min of reperfusion. Changes in infarct size and serum cTnT (cardiac troponin T) caused by I/R were reduced by exercise training. Moreover, cardiac dysfunction caused by I/R was also alleviated by exercise training. These effects of exercise training were reversed by nor-BNI (a selective K-OR antagonist), Compound C (a selective AMPK inhibitor), Akt inhibitor and L-NAME (a nonselective eNOS inhibitor). Expression of K-OR and phosphorylation of AMPK, Akt and eNOS were significantly increased in the ME, HE and AE groups. These findings demonstrated that the cardioprotective effect of exercise training is possibly mediated by the K-ORAMPK-Akt-eNOS signaling pathway.
学科主题	Science & Technology - Other Topics
出版地	SAN FRANCISCO
资助项目	国家自然科学基金项目
项目编号	National Natural Science Foundation of China [81270402] ; National Natural Science Foundation of Shaanxi Province [2016KTCL03]
语种	英语
WOS记录号	WOS:000396318300005
资助机构	NSFC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/188651]
专题	第一临床医学院_期刊论文
通讯作者	Pei, JM (reprint author), Fourth Mil Med Univ, Natl Key Discipline Cell Biol, Dept Physiol, Xian, Shaanxi Provinc, Peoples R China.; Chen, WS (reprint author), Fourth Mil Med Univ, Xijing Hosp, Dept Cardiovasc Surg, Xian, Shaanxi Provinc, Peoples R China.
推荐引用方式 GB/T 7714	Geng, X,Zhao, HL,Zhang, SM,et al. K-opioid receptor is involved in the cardioprotection induced by exercise training[J]. PLOS ONE,2017,12(3).
APA	Geng, X.,Zhao, HL.,Zhang, SM.,Li, J.,Tian, F.,...&Chen, WS .(2017).K-opioid receptor is involved in the cardioprotection induced by exercise training.PLOS ONE,12(3).
MLA	Geng, X,et al."K-opioid receptor is involved in the cardioprotection induced by exercise training".PLOS ONE 12.3(2017).